DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and Grip2

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_006506166.1	Gene:	Grip2 / 243547	MGIID:	2681173	Length:	1049	Species:	Mus musculus

Alignment Length:	380	Identity:	87/380 - (22%)
Similarity:	134/380 - (35%)	Gaps:	110/380 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DTDGYPAFDVDSDAYATKDDSRWGFLITGGAEFHMPLTVFQVTPNGLADKAG-IRLGDIILEINE 92
            ::.|..::.|:...|.    ...|..|:|..|...|:.:..:|..|||::.| |.:||.||.||.
Mouse   657 ESSGAVSYTVELKRYG----GPLGITISGTEEPFDPIIISGLTKRGLAERTGAIHVGDRILAINS 717

  Fly    93 EDASQLTLSQAHEKINSTPKKIHFLLRNMEEDDPMGQFEAGEEKSIVMRVPKPLPPPSGRIRASS 157
            .......||:|          ||.|.            .|||  ::.:::.|.|..|
Mouse   718 VSLKGRPLSEA----------IHLLQ------------VAGE--TVTLKIKKQLDRP-------- 750

  Fly   158 IEMRLLEMQRKLSAIAEIPKILCSTLATVSQNFGRMSE-SEVDEDDVGEEEA----YVQRKFSYD 217
                ||..|.                       |.:|| |:||||   ..||    .:..:||..
Mouse   751 ----LLPRQS-----------------------GSLSEASDVDED---PPEALKGGLLATRFSPA 785

  Fly   218 EDALDFELRN-GEQA-----GDTDSDEEDLVLVREEDAEDVDVPKGAKQSKLLKDVTP-ESDYAS 275
            ..::|..:.: |..|     |.|.|.... |.||..      .|:..:.|:|.....| |....|
Mouse   786 VPSVDSAVESWGSSATDGGFGGTGSYTPQ-VAVRSV------TPQEWRPSRLKSSPPPLEPRRTS 843

  Fly   276 EANYPANEASDDTESDDEDE------PGSTVYFMKLPAAAAEDTYSSTEDE-----DDSDFLNTT 329
            ....|::|:..:.|.|.|..      |.....|.::...|.||..|..:.|     :.|....|.
Mouse   844 YTPGPSDESFPEEEGDWEPPMSPAPGPAREEGFWRVLGEALEDLESCGQSELLRELEASIMTGTV 908

  Fly   330 YTWNLRNVPKLRINDAEAEGELTLGHQAREVPQQEQPQEKQPCLEPEPPKVRPAT 384
            ::..:...|..|           ...::|||  :..|::.|..|.|.|.::...|
Mouse   909 HSVAVDGRPGSR-----------PWRRSREV--RTSPEDLQELLLPTPLEMHRVT 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	23/74 (31%)
Grip2	XP_006506166.1	PDZ_signaling	58..140	CDD:238492
		PDZ_signaling	160..243	CDD:238492
		PDZ_signaling	258..341	CDD:238492
		PDZ_signaling	463..551	CDD:238492
		PDZ_signaling	564..647	CDD:238492
		PDZ_signaling	664..744	CDD:238492	28/107 (26%)
		PDZ_signaling	947..1026	CDD:238492	1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810