DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and GRIP1

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_016874587.1	Gene:	GRIP1 / 23426	HGNCID:	18708	Length:	1188	Species:	Homo sapiens

Alignment Length:	425	Identity:	89/425 - (20%)
Similarity:	140/425 - (32%)	Gaps:	157/425 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GFLITGGAEFHMPLTVFQVTPNGLADKAG-IRLGDIILEINEEDASQLTLSQAHEKINSTPKKIH 115
            |..|:|..|...|:.:..:|..|||::.| |.:||.||.||........||:|          ||
Human   759 GITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEA----------IH 813

  Fly   116 FLLRNMEEDDPMGQFEAGEEKSIVMRVPKPLPPPSGRIRASSIEMRLLEMQRKLSAIAEIPKILC 180
            .|..            |||  ::.:::.|.....|    |||  .:...:...||.:.::.:.
Human   814 LLQM------------AGE--TVTLKIKKQTDAQS----ASS--PKKFPISSHLSDLGDVEED-- 856

  Fly   181 STLATVSQNFGRMSE---SEVDEDDVGEEEAYVQRKFSYDEDALDFEL---RNGEQAGDTDSDEE 239
               ::.:|..|::|:   |.|...|...:        |:|..|:|...   ....||...:.:..
Human   857 ---SSPAQKPGKLSDMYPSTVPSVDSAVD--------SWDGSAIDTSYGTQGTSFQASGYNFNTY 910

  Fly   240 DLVLVREEDAEDVDVPKGAKQSKLLKDVTPESDYASEANYPANEASDDTESDDEDEPGSTVYFMK 304
            |.              :..||...|..||.          |.::...|.....||...||....
Human   911 DW--------------RSPKQRGSLSPVTK----------PRSQTYPDVGLSYEDWDRSTASGF- 950

  Fly   305 LPAAAAEDTYSSTEDEDDSDFLNTTYTWNLRNVPKLRINDAEAEGE----------------LTL 353
              |.||:    |.|.|.:.:|      |:      ..:.|.|..|:                ::|
Human   951 --AGAAD----SAETEQEENF------WS------QALEDLETCGQSGILRELEATIMSGSTMSL 997

  Fly   354 GHQAREVPQQEQPQEKQPCLEPEPPKVRPATPTPKAPPQESAEGQTQKLLFRLDKLERSWPWADR 418
            .|:|                           |||::.....|..|           |||     .
Human   998 NHEA---------------------------PTPRSQLGRQASFQ-----------ERS-----S 1019

  Fly   419 EKIIYKQST-CHLVPRKPLGLVGQRMQLLLKDKKE 452
            .:..|.|:| .:.:|..    ||::...|.|.|:|
Human  1020 SRPHYSQTTRSNTLPSD----VGRKSVTLRKMKQE 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	23/67 (34%)
GRIP1	XP_016874587.1	PDZ_signaling	128..208	CDD:238492
		PDZ_signaling	227..310	CDD:238492
		PDZ_signaling	325..408	CDD:238492
		PDZ_signaling	545..633	CDD:238492
		PDZ_signaling	646..730	CDD:238492
		PDZ_signaling	746..827	CDD:238492	26/91 (29%)
		PDZ_signaling	1062..1142	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810