DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and alp-1

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001023371.1	Gene:	alp-1 / 177701	WormBaseID:	WBGene00001132	Length:	1424	Species:	Caenorhabditis elegans

Alignment Length:	465	Identity:	96/465 - (20%)
Similarity:	164/465 - (35%)	Gaps:	126/465 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PESKSKAPIIKVSCGIGDTDGYPAFDVDSDAYATKDDSR-WGFLITGGAEFHMPLTVFQVTPNGL 75
            |.:....|.:.::            |:.:......:.|| |...::..|.  .|:.:.:.....:
Worm   737 PSTPLSVPTVSIN------------DIATSPIKITEPSRPWRASVSNSAT--SPIKIHESRVQPV 787

  Fly    76 ADKAGIRLGDIILEINEEDASQLTLS--QAHEKINSTPKKIH-FLLRNMEEDDPMGQFEAGEEKS 137
            .:..|:.        ..|:.:|:..|  :.||. :|.|..:| |...|........||.  :...
Worm   788 DESRGLH--------RHEEKAQIETSTIKIHEP-SSPPPSVHKFGAVNTRAAPAPVQFM--QTPR 841

  Fly   138 IVMRV-----PKPLPP--PSGRIRASSIEMRLLEMQRKLSAIAEIPKILCSTLATVSQNFGRMSE 195
            |.:::     |.|.||  ||..|:......:.::..:....:  ||:             .:.|.
Worm   842 IAVKIHEPTGPSPTPPSTPSHPIKRDPKHFKKVDFSKTSPTV--IPE-------------WKDSA 891

  Fly   196 SEVDEDDVGEEEAYVQRKFSYDEDALDFELRNGEQAGDTD-------SDEEDLVLVREEDAEDVD 253
            ..|||.|:..|       .|.::|::.| |:.....||..       .::.|:....:.:.|:||
Worm   892 DIVDESDILTE-------CSREDDSISF-LKAATYDGDESEMIDNNIDNKSDITSTFDIEEEEVD 948

  Fly   254 VPKGAKQSKLLKDVTPESDYASEA-NYPANEASDDTESDDEDEPGSTVYFMKLPAAAAEDTYSST 317
            |.:..::.:::.....|...|.:. ...|.|..||....:.|        :::.||..|......
Worm   949 VVQDRERIRVVGRKGGEGGEAEKQWRQRAMELLDDDAQTERD--------LRIVAALNERLQGLR 1005

  Fly   318 EDEDD-----------------------SDFLNT--TYTWNLRNVPKLRI-----NDAEA----E 348
            |.|||                       |..|.:  .|..|||  |:|.:     |||::    :
Worm  1006 EMEDDDRVRAIECIARHQSELEQTQTQLSTLLESAIVYLQNLR--PELELTEPIDNDAKSLETVK 1068

  Fly   349 GELTLGHQ-AREVPQQE-QPQEKQPCL------EPEPPKVRPATP----TPKAP--PQESAEGQ- 398
            .|.|...| ..|:.::. :..|..|.|      .|.||..|...|    .|.||  |..:||..
Worm  1069 FEPTRAEQRVNEIRKKVLEDLEHLPILGDGMDSVPPPPPERKVFPFQSYQPIAPQFPVPAAESPV 1133

  Fly   399 TQKLLFRLDK 408
            ||.|...||:
Worm  1134 TQSLHDVLDE 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	15/77 (19%)
alp-1	NP_001023371.1	PDZ_signaling	5..80	CDD:238492
		DUF4749	137..>197	CDD:292558
		ZM	137..162	CDD:128974
		LIM_ALP_like	220..271	CDD:188746
		LIM1_Enigma_like_1	1251..1304	CDD:188839
		LIM	1312..1363	CDD:295319
		LIM3_Enigma_like_1	1371..1424	CDD:188845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100