DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and Grip2

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_612544.2	Gene:	Grip2 / 171571	RGDID:	621668	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	86/385 - (22%)
Similarity:	130/385 - (33%)	Gaps:	119/385 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DTDGYPAFDVDSDAYATKDDSRWGFLITGGAEFHMPLTVFQVTPNGLADKAG-IRLGDIILEINE 92
            ::.|..::.|:...|.    ...|..|:|..|...|:.:..:|..|||::.| |.:||.||.||.
  Rat   650 ESSGAVSYTVELKRYG----GPLGITISGTEEPFDPIIISGLTKRGLAERTGAIHVGDRILAINS 710

  Fly    93 EDASQLTLSQAHEKINSTPKKIHFLLRNMEEDDPMGQFEAGEEKSIVMRVPKPLPPPSGRIRASS 157
            .......||:|          ||.|.            .|||  ::.:::.|.|..|
  Rat   711 VSLKGRPLSEA----------IHLLQ------------VAGE--TVTLKIKKQLDRP-------- 743

  Fly   158 IEMRLLEMQRKLSAIAEIPKILCSTLATVSQNFGRMSE-SEVDEDDVGEEEA----YVQRKFSYD 217
                ||..|.                       |.:|| |:||||   ..||    .:...||..
  Rat   744 ----LLPRQS-----------------------GSLSEASDVDED---PPEALKGGLLTTHFSPA 778

  Fly   218 EDALDFELRN-GEQA-----GDTDSDEEDLVLVREEDAEDVDVPKGAKQSKLLKDVTP-ESDYAS 275
            ..::|..:.: |..|     |.:.|.... |.||..      .|:..:.|:|.....| |....|
  Rat   779 VPSVDSAVESWGSSATEGGFGGSGSYTPQ-VAVRSV------TPQEWRSSRLKSSPPPLEPRRTS 836

  Fly   276 EANYPANEASDDTESDDEDEPGSTVYFMKLPAAAAEDTYSSTEDEDDSDFLNTTYTWNLRNVPKL 340
            ....|.:|:..:.|..|.:.|.|..     |..|.|:.:.....|...|..:...:..||
  Rat   837 YTPGPTDESFPEEEEGDWEPPMSPA-----PGPAREEGFWRVLGEALEDLESCGQSELLR----- 891

  Fly   341 RINDAEAEGELTLG----------------HQAREVPQQEQPQEKQPCLEPEPPKVRPAT 384
                 |.|..:..|                .::|||  ...|::.|..|.|.|.::...|
  Rat   892 -----ELEASIMTGTVQSVAVDGRPGSRPWRRSREV--GTSPEDLQELLLPTPLEMHRVT 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	23/74 (31%)
Grip2	NP_612544.2	PDZ_signaling	51..133	CDD:238492
		PDZ_signaling	153..236	CDD:238492
		PDZ_signaling	251..334	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..450
		PDZ_signaling	456..544	CDD:238492
		PDZ_signaling	557..640	CDD:238492
		PDZ_signaling	657..737	CDD:238492	28/107 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..769		12/49 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..863		19/88 (22%)
		PDZ_signaling	941..1020	CDD:238492	1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810