DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and pdzd7a

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001177686.1	Gene:	pdzd7a / 100332580	ZFINID:	ZDB-GENE-090313-191	Length:	954	Species:	Danio rerio

Alignment Length:	489	Identity:	105/489 - (21%)
Similarity:	165/489 - (33%)	Gaps:	147/489 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 YATKDDSRWGFLITGGAEFHMPLTVFQVTPNGLADKAGIRLGDIILEINEEDASQLTLSQAHEKI 107
            |.|.||...||.|.||.||.:.:.|.::.|.|||::.||::||.||..|......:|.|.|.|.:
Zfish   199 YTTSDDYCLGFNIRGGKEFGLGIYVSKLDPGGLAEQNGIKMGDQILAANGVSFEDITHSNAVEVL 263

  Fly   108 NSTPKKIHFLLRNMEEDDPMGQFEAGEEK----SIVMRVPKPLPPPSGRIRASSIEMRLLEMQRK 168
            .|   ..|.:|...|    .|::.|.:|.    |.:.::.....|.|.:...|......|.....
Zfish   264 KS---HTHVMLTIKE----AGRYPAYKEMVAEYSWLNKLANGGQPSSSQGSDSYSSTSSLSSGTP 321

  Fly   169 LSAIAEIPKILCSTLATVSQNFGRMSESEVDEDDVGEEEAYVQRKFSYDEDALDFELRNGEQAGD 233
            :|:::.:.::      |....||    ||:.:..:..|:    |......:.::..::...|..|
Zfish   322 VSSLSGLSQV------TFPPAFG----SEMVDVCISTED----RSRRPSSERIETAIQTDPQDPD 372

  Fly   234 TDSDEE------------DLVLVREE-----------------DAEDVDVPKGA---KQSKLLKD 266
            |.|...            :.||:::.                 |.|.:|.||.|   ..||..|.
Zfish   373 TISRTSRVMSTETSRMVGETVLLKDTVIRRGTAHSRTRTFSAGDKETLDSPKTAVLMALSKPRKA 437

  Fly   267 VTPESDY--ASEANYPANEAS----DDTESDDEDE-------------PGSTVY----FMKLP-A 307
            :.....:  .||..:....||    ..:.|..||:             .|||:.    |:.|| .
Zfish   438 IRRSQSHITVSEFWFATERASCLCGCTSRSRQEDKQKKRKHQKGKVETEGSTLQRSKTFVTLPFK 502

  Fly   308 AAAEDTYSSTEDEDDSDFLNTTYTWNLRNVPKLRINDAEAEGELTLGHQAREVPQQEQPQEKQPC 372
            :......||:.|..|:...:                          ||:.|    .:.|:.
Zfish   503 SGRRRERSSSRDRKDTGRED--------------------------GHKGR----SKSPKH---- 533

  Fly   373 LEPEPPK-------------------VRPATPTPKAPPQESAEGQTQKLLFRLDKLERSWPWADR 418
            |:.||.|                   :|..:|.|........|...:|||..           |.
Zfish   534 LDNEPGKERGRPIINLLSSPRETRAGLREQSPMPSPETMALLEDVARKLLNE-----------DE 587

  Fly   419 EKIIYKQSTCHLVPRKPLGLVGQRMQLLLKDKKE 452
            ...:.:.....||.|....||  |..|.:.||.|
Zfish   588 VAAVMRHCKRFLVDRVVEDLV--RPLLAILDKPE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	28/73 (38%)
pdzd7a	NP_001177686.1	PDZ_signaling	69..149	CDD:238492
		PDZ_signaling	194..274	CDD:238492	30/77 (39%)
		HN_PDZD7_like	568..645	CDD:259824	15/65 (23%)
		PDZ_signaling	860..948	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910