DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mp20 and Iqgap3

DIOPT Version :9

Sequence 1:	NP_001014522.2	Gene:	Mp20 / 36468	FlyBaseID:	FBgn0002789	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_001028656.1	Gene:	Iqgap3 / 404710	MGIID:	3028642	Length:	1632	Species:	Mus musculus

Alignment Length:	179	Identity:	51/179 - (28%)
Similarity:	81/179 - (45%)	Gaps:	46/179 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AVRAKIASKR--NPEMD---------------KEAQEWIEAIIAEKFPAGQSYEDVLKDGQVLCK 53
            |.||:.|.:|  ..|||               :||:.|:|..:.|:.|:....|:.|::|.:|.|
Mouse     6 AGRARTAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEVCLKEELPSPVELEESLRNGVLLAK 70

  Fly    54 LINVLSPNAVP----------KVNSSGGQFKFMENINNFQKALKEYGVPDIDVFQTVDLYEKKDI 108
            |.:..:|:.||          :..::|..|:..:|||.:..|:...|:|.|.:.:|.|:|:||::
Mouse    71 LGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAVAHIGLPSIFLPETTDIYDKKNM 135

  Fly   109 ANVTNTI-------FALGRATYKHADFKGPFLGPKPADECKRDFTEEQL 150
            ..|...|       |.||.|...| |..|           |..||.|:|
Mouse   136 PRVIYCIHALSLFLFRLGLAPQIH-DLYG-----------KVKFTAEEL 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mp20	NP_001014522.2	SCP1	7..179	CDD:227526	50/178 (28%)
		CH	18..121	CDD:237981	37/134 (28%)
		Calponin	158..178	CDD:278814
Iqgap3	NP_001028656.1	CH	35..147	CDD:237981	31/111 (28%)
		IQ	764..782	CDD:197470
		RasGAP	977..1328	CDD:214617
		RasGAP	988..1337	CDD:295371
		RasGAP_C	1434..1555	CDD:281787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2278
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940