DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mp20 and TAGLN3

DIOPT Version :9

Sequence 1:	NP_001014522.2	Gene:	Mp20 / 36468	FlyBaseID:	FBgn0002789	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_001008273.1	Gene:	TAGLN3 / 29114	HGNCID:	29868	Length:	199	Species:	Homo sapiens

Alignment Length:	190	Identity:	81/190 - (42%)
Similarity:	113/190 - (59%)	Gaps:	11/190 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LERAVRAKIASKRNPEMDKEAQEWIEAIIAEKF---PAGQS-YEDVLKDGQVLCKLINVLSP--- 60
            |.|.|:.||..|.:.:::.:..:||....||..   |.|:: ::..|.||.|||||||.|.|
Human    10 LSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGTVLCKLINSLYPPGQ 74

  Fly    61 NAVPKVNSSGGQFKFMENINNFQKALKEYGVPDIDVFQTVDLYEKKDIANVTNTIFALGRATYKH 125
            ..:||::.|...||.||.|:.|.||.:.|||...|:||||||:|.||:|.|..|:.|||......
Human    75 EPIPKISESKMAFKQMEQISQFLKAAETYGVRTTDIFQTVDLWEGKDMAAVQRTLMALGSVAVTK 139

  Fly   126 AD--FKG-PFLGPKPADECKRDFTEEQLKAGQTIVGLQAGSNKGATQAGQ-NLGAGRKIL 181
            .|  ::| |....:.|.:.:|.|:||||:.||.::|||.||||||:|||. ..|..|:|:
Human   140 DDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGSNKGASQAGMTGYGMPRQIM 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mp20	NP_001014522.2	SCP1	7..179	CDD:227526	77/182 (42%)
		CH	18..121	CDD:237981	48/109 (44%)
		Calponin	158..178	CDD:278814	13/20 (65%)
TAGLN3	NP_001008273.1	CH_TAGLN3	23..141	CDD:409130	48/117 (41%)
		Calponin-like	174..199		14/24 (58%)
		Calponin	174..198	CDD:395325	14/23 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..199		13/22 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144835
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D488325at33208
OrthoFinder	1	1.000	-	-		FOG0000270
OrthoInspector	1	1.000	-	-		mtm8439
orthoMCL	1	0.900	-	-		OOG6_102866
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2278
SonicParanoid	1	1.000	-	-		X194
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.680