DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mp20 and IQGAP3

DIOPT Version :9

Sequence 1:	NP_001014522.2	Gene:	Mp20 / 36468	FlyBaseID:	FBgn0002789	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	XP_024309041.1	Gene:	IQGAP3 / 128239	HGNCID:	20669	Length:	1643	Species:	Homo sapiens

Alignment Length:	190	Identity:	53/190 - (27%)
Similarity:	84/190 - (44%)	Gaps:	46/190 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KEAQEWIEAIIAEKFPAGQSYEDVLKDGQVLCKLINVLSPNAVP----------KVNSSGGQFKF 75
            :||:.|:||.:.|:.|:....|:.|::|.:|.||.:..:|:.||          :..::|..|:.
Human    43 EEAKRWMEACLKEELPSPVELEESLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRH 107

  Fly    76 MENINNFQKALKEYGVPDIDVFQTVDLYEKKDIANVTNTI-------FALGRATYKHADFKGPFL 133
            .:|||.:..|:...|:|.....:|.|:|:||::..|...|       |.||.|...| |..|
Human   108 TDNINFWLSAIAHIGLPSTFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLAPQIH-DLYG--- 168

  Fly   134 GPKPADECKRDFTEEQLKAGQTIVGLQAGSNKGATQA--GQNLGAGRK---ILLGKVIID 188
                    |..||.|:|            ||..:..|  |..|.|..|   ||..::.:|
Human   169 --------KVKFTAEEL------------SNMASELAKYGLQLPAFSKIGGILANELSVD 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mp20	NP_001014522.2	SCP1	7..179	CDD:227526	49/176 (28%)
		CH	18..121	CDD:237981	34/116 (29%)
		Calponin	158..178	CDD:278814	6/21 (29%)
IQGAP3	XP_024309041.1	RasGAP_C	16..>209	CDD:332048	53/190 (28%)
		Myosin_head	<746..>969	CDD:332202
		RasGAP_C	<873..1643	CDD:332048
		RasGAP_IQGAP3	999..1348	CDD:213346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2278
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940