DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mp20 and Cnn2

DIOPT Version :9

Sequence 1:	NP_001014522.2	Gene:	Mp20 / 36468	FlyBaseID:	FBgn0002789	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_031751.1	Gene:	Cnn2 / 12798	MGIID:	105093	Length:	305	Species:	Mus musculus

Alignment Length:	180	Identity:	64/180 - (35%)
Similarity:	107/180 - (59%)	Gaps:	4/180 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LERAVRAKIASKRNPEMDKEAQEWIEAIIAEKFPAGQSYEDVLKDGQVLCKLINVLSPNAVPKVN 67
            |...|:.::.||.:|:.:.|.:.|||.:..  ...|..::..||||.:||.|:|.|.|.:|||:|
Mouse    14 LSAEVKNRLLSKYDPQKEAELRSWIEGLTG--LSIGPDFQKGLKDGVILCTLMNKLQPGSVPKIN 76

  Fly    68 SSGGQFKFMENINNFQKALKEYGVPDIDVFQTVDLYEKKDIANVTNTIFAL-GRATYKHADFKGP 131
            .|...:..:||::||.||:..||:..:|:|:..||:|..::..|..::.|| |:|..|... .|.
Mouse    77 RSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKAKTKGLQ-SGV 140

  Fly   132 FLGPKPADECKRDFTEEQLKAGQTIVGLQAGSNKGATQAGQNLGAGRKIL 181
            .:|.|.:::.:|:|.:..:||||.::|||.|:||.|:|:|......|:.|
Mouse   141 DIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSGMTAYGTRRHL 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mp20	NP_001014522.2	SCP1	7..179	CDD:227526	61/172 (35%)
		CH	18..121	CDD:237981	37/103 (36%)
		Calponin	158..178	CDD:278814	9/19 (47%)
Cnn2	NP_031751.1	SCP1	19..190	CDD:227526	61/173 (35%)
		CH	31..127	CDD:278723	34/97 (35%)
		Calponin-like 1	166..191		11/25 (44%)
		Calponin	166..189	CDD:278814	10/22 (45%)
		Calponin-like 2	206..231
		Calponin	206..229	CDD:278814
		Calponin-like 3	245..269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834938
Domainoid	1	1.000	89	1.000	Domainoid score	I7812
eggNOG	1	0.900	-	-		E1_COG5199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3215
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D488325at33208
OrthoFinder	1	1.000	-	-		FOG0000270
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2278
SonicParanoid	1	1.000	-	-		X194
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.780