DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mp20 and CNN2

DIOPT Version :9

Sequence 1:	NP_001014522.2	Gene:	Mp20 / 36468	FlyBaseID:	FBgn0002789	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_001290430.1	Gene:	CNN2 / 1265	HGNCID:	2156	Length:	330	Species:	Homo sapiens

Alignment Length:	200	Identity:	64/200 - (32%)
Similarity:	108/200 - (54%)	Gaps:	23/200 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LERAVRAKIASKRNPEMDKEAQEWIEAIIAEKFPAGQSYEDVLKDGQVLCKLINVLSPNAVPKVN 67
            |...|:.::.||.:|:.:.|.:.|||.:..  ...|..::..||||.:||.|:|.|.|.:|||:|
Human    14 LSAEVKNRLLSKYDPQKEAELRTWIEGLTG--LSIGPDFQKGLKDGTILCTLMNKLQPGSVPKIN 76

  Fly    68 SSGGQFKFMENINNFQKALKEYGVPDIDVFQTVDLYEKKDIANVTNTIFAL-GRA---------- 121
            .|...:..:||::||.||:..||:..:|:|:..||:|..::..|..::.|| |:.
Human    77 RSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKGLDLGSLAALC 141

  Fly   122 ------TYKHADFK----GPFLGPKPADECKRDFTEEQLKAGQTIVGLQAGSNKGATQAGQNLGA 176
                  :...|..|    |..:|.|.:::.:|:|.:..:||||.::|||.|:||.|:|:|.....
Human   142 WYSRPLSLTQAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSGMTAYG 206

  Fly   177 GRKIL 181
            .|:.|
Human   207 TRRHL 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mp20	NP_001014522.2	SCP1	7..179	CDD:227526	61/192 (32%)
		CH	18..121	CDD:237981	37/103 (36%)
		Calponin	158..178	CDD:278814	9/19 (47%)
CNN2	NP_001290430.1	Calponin	19..211	CDD:332521	61/193 (32%)
CNN2	NP_001290430.1	Calponin	227..250	CDD:306832
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144830
Domainoid	1	1.000	89	1.000	Domainoid score	I7831
eggNOG	1	0.900	-	-		E1_COG5199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3215
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D488325at33208
OrthoFinder	1	1.000	-	-		FOG0000270
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2278
SonicParanoid	1	1.000	-	-		X194
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.780