DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4679 and let-630

DIOPT Version :9

Sequence 1:	NP_610854.1	Gene:	CG4679 / 36466	FlyBaseID:	FBgn0033816	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_491536.2	Gene:	let-630 / 172153	WormBaseID:	WBGene00002804	Length:	664	Species:	Caenorhabditis elegans

Alignment Length:	708	Identity:	179/708 - (25%)
Similarity:	303/708 - (42%)	Gaps:	136/708 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IACSLSSSGAHYTTAAPAEDAPIEIPNRIERSPTDLLQALASTVARDYTAPHYKYHDDPFLIPMS 79
            |..||||       ..||....:.|...|||||||||.||:.||..|.||||:.|.|||..||.:
Worm    11 ITRSLSS-------VEPALSQKLTIQPAIERSPTDLLNALSETVGPDTTAPHFAYIDDPITIPST 68

  Fly    80 NAAKRTYAMSKESGRKAAKWIKEEHRELFMHQEAQPAIEKFAPSMVYTEDSV-VDETSLAQLISQ 143
            .:.|:||.|:||.|::||:.:..|...||.....||.:..|.|..:.....| ..|.:|.::||.
Worm    69 QSTKKTYFMAKEFGKRAARELATEWPTLFAFDRDQPQLPVFRPRHLADPLQVEPTENNLLKMISS 133

  Fly   144 GELKDAVLVYNLLEQKGNPISPELKQSLLELVCFHNNQEPIP----EEYIEERWFLQNNKRRERS 204
            .|:||:.::|..:..:...:|.:::..|..||.::|:.. :|    ||::..|.|      .|.|
Worm   134 REVKDSCILYERMRSENVDVSEKVQLELFRLVTYYNSSN-VPFAEWEEFVGMRNF------GEDS 191

  Fly   205 GKTWKDGDLAEKLYSEIEPKTPQSYASLIRGMAKY---LQCERAYALLQEAGEKQVQLDTNTFNS 266
            ..:||.|.:|:.|: |..|||.::.:.:|.|:.|:   ...|||..|.:|....:.::....||.
Worm   192 TSSWKSGAVADLLF-ETLPKTDETVSIMIAGLCKFSDHSSLERARELYKEHRAAKGKVYREAFNG 255

  Fly   267 VIEIVSFLKDTAEQRWQLCKDLLNEMSQQKLRPNLGTLNAVLQCISTFGNFKVARAAALQALPEF 331
            :|...|:         .:.|.|:.||...::.|::.|.||:|...:..|.|:....|..:.:.|.
Worm   256 LIGASSY---------SVGKKLVAEMISLRMTPDIFTFNALLSSAAKAGKFEDRVKAFTEIIGEM 311

  Fly   332 KQLGVNPSLGSYYYLL--IIFCR-----------ERGPVSHVIV-------DILNDISGKEFQIQ 376
            |::||.|:|.|::.::  ||..:           ::...:|.:.       :|.|.::||..:..
Worm   312 KEIGVEPALSSFHLIIKNIIDFKLLDNEKRESDEQKKTYNHQLTVAISWLNEIQNSLTGKTLKPI 376

  Fly   377 HPKDTYFFATAMDVCRNHLH--DKSLAKKVDELLHTGKNYDLVGDSFKESIYYRNYLALLCQTES 439
            ......||..||.:   |..  :::||:.:..:..:..|...:.....||::|...|.|  ..|.
Worm   377 TSTCNLFFVEAMGI---HYRAANENLAENLVSIYESKANEVKMPAFTIESMFYNRQLQL--AVEQ 436

  Fly   440 TEDFMLSYDL---LVP-----NIYIPE--------------PGIMEEILRAI---EINGAV--EY 477
            :......|||   :||     |.|:..              |.:...|:..|   ::||.:  |.
Worm   437 SASLNRIYDLYTTMVPRLVGVNNYLSSLVFRKLAASSDRHWPLLRRVIIDGIAAGQMNGVIGEEM 501

  Fly   478 VPRLWSDMVVFDHT----HRESLLLYVLRILVDNKPNPDSPAQAQLPEQGAKVALDMFERVEEAI 538
            ..:|.:..:   ||    .||.....|.:::.                    |.::..:..||.:
Worm   502 RKQLCNVQL---HTLGTSEREQFTSLVQKLVA--------------------VWVEFSQFTEERM 543

  Fly   539 KRL-RKVSFTGQMLGDILTLLVRGGSYEKATEVF-------------AHIDKNQHRIPGTPSLNA 589
            :|| ||:|  ...:.:...||.|.|..:||.|:.             |.:....|..|.     |
Worm   544 RRLQRKLS--PSQISECALLLTRIGEQQKAYELLDLLLDETASSGDEATVYPRGHARPW-----A 601

  Fly   590 LIEFVDASVQEKSPSQALFALQY--AVENNFDSRELAKRIHEGFTLNETHLSKLKSLV 645
            :.|..:.:::::....|...||.  ...|......||.||.|...:|:..:..::..:
Worm   602 MAELFEDALRKRDTYAAATCLQIMSLTANRAKLEPLANRIFEKCNVNQEQVRIIQGFI 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4679	NP_610854.1	PLN03218	<210..>348	CDD:215636	38/142 (27%)
		PPR repeat	228..255	CDD:276811	8/29 (28%)
		PPR repeat	261..295	CDD:276811	8/33 (24%)
let-630	NP_491536.2	PPR repeat	214..244	CDD:276811	8/29 (28%)
		PPR repeat	250..275	CDD:276811	8/33 (24%)
		PPR_3	267..332	CDD:316342	19/64 (30%)
		PPR repeat	281..313	CDD:276811	8/31 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166424
Domainoid	1	1.000	123	1.000	Domainoid score	I3465
eggNOG	1	0.900	-	-		E1_KOG4422
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I2901
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46509
OrthoDB	1	1.010	-	-		D197549at33208
OrthoFinder	1	1.000	-	-		FOG0005556
OrthoInspector	1	1.000	-	-		oto18035
orthoMCL	1	0.900	-	-		OOG6_106573
Panther	1	1.100	-	-	LDO	PTHR16276
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4311
SonicParanoid	1	1.000	-	-		X4519
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840