DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4676 and Zdhhc2

DIOPT Version :9

Sequence 1:	NP_610853.1	Gene:	CG4676 / 36465	FlyBaseID:	FBgn0033815	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_848482.1	Gene:	Zdhhc2 / 70546	MGIID:	1923452	Length:	366	Species:	Mus musculus

Alignment Length:	200	Identity:	58/200 - (28%)
Similarity:	82/200 - (41%)	Gaps:	37/200 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 CQDCQTLVPPRSWHCEVCNVCVLKRDHHCRFTCCCIGHHNYRYFFYYLVYMIIGSLAAAIMESIY 163
            |..||.:.|.|..||.||:.|:||.||||.:...|:|..||::|..:|.|.::..|..|..:..|
Mouse   128 CDRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCLFIAATDLQY 192

  Fly   164 ---LWHLHL-DIYWRWSTLFTIFAPVVSLMLSPSWESFYLVIYDLTLLGFAI------SSLLLVF 218
               .|...| |...::..:|..||   :.|.|.|..|         |.|:..      .|.|..|
Mouse   193 FIRFWTNGLPDTQAKFHIMFLFFA---AAMFSVSLSS---------LFGYHCWLVSKNKSTLEAF 245

  Fly   219 HWSIFKSGSVTRERGTRKYDRGLRGNLEMVLGKRMHLTWLSPFLRSDLPHDG-------MNWEPI 276
            ...:|:.|  |.:.|   :..|...|:..|.|..... ||.|...|.  .||       :|.:|.
Mouse   246 RNPVFRHG--TDKNG---FSLGFSKNMRQVFGDEKKY-WLLPVFSSQ--GDGCSFPTCLVNQDPE 302

  Fly   277 AAFSP 281
            ...:|
Mouse   303 QPSTP 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4676	NP_610853.1	zf-DHHC	99..232	CDD:279823	44/142 (31%)
Zdhhc2	NP_848482.1	DHHC	126..247	CDD:366691	41/130 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..366		2/11 (18%)
		Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000269\|PubMed:21471008	298..366		2/9 (22%)
		Non-canonical dileucine endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	334..335
		NPxY-like endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	357..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810