DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4676 and ZDHHC13

DIOPT Version :9

Sequence 1:	NP_610853.1	Gene:	CG4676 / 36465	FlyBaseID:	FBgn0033815	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_061901.2	Gene:	ZDHHC13 / 54503	HGNCID:	18413	Length:	622	Species:	Homo sapiens

Alignment Length:	274	Identity:	69/274 - (25%)
Similarity:	106/274 - (38%)	Gaps:	66/274 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FLLVAVFVPVTYIFHVTIVMPELFAIGGI-WYTLLWLASLF-----------LIFNITSNM---L 70
            |.|.::|......:...:.:|..|.:..: |..:.|....|           .||:|.:.:   .
Human   328 FFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILFFPDLAGAPFYFSFIFSIVAFLYFFY 392

  Fly    71 ACMLVD---TSIRKELLKPPLDAAQLARWHS------CQDCQTLVPPRSWHCEVCNVCVLKRDHH 126
            .....|   |...:|..|  ::...||...|      |..|....|.||.||.|||.||.:.|.|
Human   393 KTWATDPGFTKASEEEKK--VNIITLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNCCVARYDQH 455

  Fly   127 CRFTCCCIGHHNYRYFFYYLVYM-------IIGSLAAAIMESIYLWHLHLDIYWRWSTLFTIFAP 184
            |.:|..|||..|:.|:.::|.::       |.||.       ||| ..|....::...|:|....
Human   456 CLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSF-------IYL-SSHCATTFKEDGLWTYLNQ 512

  Fly   185 VVS--------LMLSP---SWESFYLV--IYDLTLLGFAISSLLLVFHWSIF---KSGSVTRERG 233
            :|:        |||:.   ||.:|.|:  ::.:..||       |..|..|.   :|..:.:...
Human   513 IVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLG-------LTSHERISLQKQSKHMKQTLS 570

  Fly   234 TRK--YDRGLRGNL 245
            .||  |:.|...||
Human   571 LRKTPYNLGFMQNL 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4676	NP_610853.1	zf-DHHC	99..232	CDD:279823	45/155 (29%)
ZDHHC13	NP_061901.2	ANK 1. /evidence=ECO:0000250\|UniProtKB:Q8IUH5	43..78
		ANK	79..192	CDD:238125
		ANK repeat	81..112	CDD:293786
		ANK 2. /evidence=ECO:0000255	81..110
		ANK repeat	114..146	CDD:293786
		ANK 3. /evidence=ECO:0000255	115..144
		ANKYR	<145..271	CDD:223738
		ANK repeat	148..179	CDD:293786
		ANK 4. /evidence=ECO:0000255	148..177
		ANK repeat	181..247	CDD:293786
		ANK 5. /evidence=ECO:0000255	181..211
		ANK 6. /evidence=ECO:0000255	216..245
		ANK 7. /evidence=ECO:0000255	249..277
		zf-DHHC	423..559	CDD:307600	44/150 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810