DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Qsox1 and qsox1

DIOPT Version :9

Sequence 1:	NP_001286383.1	Gene:	Qsox1 / 36464	FlyBaseID:	FBgn0033814	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_002937004.1	Gene:	qsox1 / 613045	XenbaseID:	XB-GENE-944881	Length:	741	Species:	Xenopus tropicalis

Alignment Length:	542	Identity:	179/542 - (33%)
Similarity:	274/542 - (50%)	Gaps:	37/542 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GLYDDGDKVIRLSVDNFNATVLDQNRGALV-EFYNTYCGHCRRFAPTYKSVAEHLLPWSEVLIVA 106
            |||...:.|:.|  |....|.|..:|...| |||.::||||:||.|::..:||.:..|..|:.:.
Frog    25 GLYTPDEPVVHL--DRKAHTYLLGSRSFWVAEFYASWCGHCQRFKPSWSGLAEDIKDWRPVVYLG 87

  Fly   107 AIDCAAEENNGICRNYEVMGYPTLRYLGPGFQPGPQHYGQSLHTQDKNEIREILAGMVAAENLTS 171
            .||||...|...|..:.|.||||::    .|:...:...|.:.....:.::.:...::.......
Frog    88 VIDCAESSNFETCNEFGVEGYPTIK----SFKSFTKEVSQGVSEDAVHSVQALRENIITRLEEQK 148

  Fly   172 SHNNSYWPNFHYLTENDSASSLFEGLSSATEYVAVVHEPENTTLGVEVALFMTQWPAVRVRRVI- 235
            ....|.||....::..: ..:.|:  :....|:|::.|..:..:|.|..|.|.|:..|.||||:
Frog   149 DSRPSSWPPLEPISTFE-VENFFK--TKQENYLALIFEEPSMYIGRETTLDMVQYEGVSVRRVLR 210

  Fly   236 -DPAVAAKFKIDPTNLP-LSLVDRKGEITAYAPESTNGESYAKKLWDVLG--KKNITPRPVKVHQ 296
             ...:..||.|  |:.| |.|:.|.|..|....::....||...|..:.|  |||:....|..:
Frog   211 DQNDMVNKFWI--TSYPSLVLLSRNGSNTVVNLKADTRSSYTDFLRSLPGVRKKNLFIIGVANN- 272

  Fly   297 PSATPASKIKGQNELIDEVHRNKHFVYQADLEQAIRTVLHNEVSKVGEISGEKLLALQRFLAVLQ 361
                      |..|..|....:...:|.||||.|:...|..|||:...:.||:|.||..:::||:
Frog   273 ----------GTTEQDDRRIADSTKLYMADLESAVHYTLRAEVSRFSHLEGERLDALIAYVSVLR 327

  Fly   362 RYNPLGANGHQLVSKLKDYVVQFNDQRLTGSQFEEEL-KRLEAHLSPVYSSNHFVGCVGSSPRLR 425
            :|.|....|..|:..:..::.....:.:....||..| .:.||..:.:.||.::|.|.||.|..|
Frog   328 KYFPARPYGTTLLKSIHSWLHDRAGKEVLYKDFENVLNNKDEAQNAVLSSSVNYVWCQGSHPNFR 392

  Fly   426 GFSCSLWTLFHFMTVQAANNEET-QDPLEVLQAMHGYIKNFFGCTECSEHFQAMASRRKIWSVPN 489
            ||.|||||||||:||||  :|:| ..|.|||..:.||:||||||.||:.||::||: ..:.:|..
Frog   393 GFPCSLWTLFHFLTVQA--SEDTAAPPTEVLLGLRGYVKNFFGCRECAGHFESMAA-ESMNTVNT 454

  Fly   490 KEEAVLWLWAAHNEVNQRLAGDATEDPEFPKKQFPAPESCNECYRTPVSKSENLEIEWNKDAVLG 554
            .:||:||||..||.||:||||..:|||||||..:|:...|..|.    .:....|:.|:...||.
Frog   455 LDEAILWLWDRHNRVNKRLAGQPSEDPEFPKLPWPSKTLCPFCQ----VEDGGDELAWDIPNVLN 515

  Fly   555 FLKNIHNPQFVSRYGVQREELL 576
            |:|..::.|.::...::.||:|
Frog   516 FMKTHYSRQNLANDYLEDEEVL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox1	NP_001286383.1	PDI_a_QSOX	49..162	CDD:239290	34/113 (30%)
Qsox1	NP_001286383.1	Evr1_Alr	430..521	CDD:282612	53/91 (58%)
qsox1	XP_002937004.1	PDI_a_QSOX	31..142	CDD:239290	34/116 (29%)
		QSOX_Trx1	152..259	CDD:375557	30/111 (27%)
		FAD_SOX	284..387	CDD:375797	30/102 (29%)
		Evr1_Alr	396..488	CDD:368111	55/94 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5773
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37690
Inparanoid	1	1.050	258	1.000	Inparanoid score	I3055
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm9402
Panther	1	1.100	-	-	LDO	PTHR22897
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080