DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox1 and Qsox2

DIOPT Version :9

Sequence 1:	NP_001286383.1	Gene:	Qsox1 / 36464	FlyBaseID:	FBgn0033814	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001289885.1	Gene:	Qsox2 / 227638	MGIID:	2387194	Length:	692	Species:	Mus musculus

Alignment Length:	703	Identity:	192/703 - (27%)
Similarity:	310/703 - (44%)	Gaps:	138/703 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLVDIASAGVPLPRYEALLKQQSPPSDPTLGLYDDGDKVIRLSVDNFNATVLDQNRGALVEFYNT 77
            ||..:|:.|   ||.....:.....|| .:.|.|.|.  :|.:..|.:|       ..||:|:::
Mouse    32 LLAVVAAVG---PREGGGARLYREGSD-AVWLLDSGS--VRSATGNSSA-------AWLVQFHSS 83

  Fly    78 YCGHCRRFAPTYKSVAEHLLPWSEVLIVAAIDCAAEENNGICRNYEVMGYPTLRYLGPGFQPGPQ 142
            :||||..:|||::::|..:..|:..:.|||:|||.|:|..:||.|::..|||.||    |:...:
Mouse    84 WCGHCIGYAPTWRALAADVRDWAAAIRVAALDCAEEKNQDVCRTYDIHFYPTFRY----FKAFTK 144

  Fly   143 HY--GQSLHTQDKNEIREILAGMVAAENLTSSHNNSYWPNFHYLTENDSASSLFEGLSS-ATEYV 204
            .:  |::....|: |:|.:...|:   :...:|....||......:...:|.:...:.| :.:|.
Mouse   145 EFTTGENFKGPDR-ELRTVRQTMI---DFLQNHTEGTWPPACPPLDPIQSSDILSFMDSHSGQYH 205

  Fly   205 AVVHEPENTTLGVEVALFMTQWPAVRVRRVIDPAVAAKFKIDPTNLPLSLV----DRKGEITAYA 265
            |:|.|...:.:|.||.|.:..:..:.|.|.:|...|....:..|::|...:    ...|.:....
Mouse   206 AIVFESNGSYVGREVILDLIPYENIMVSRALDTDKAFLGTLGITSVPSCYLIYPNGSHGLVNVAK 270

  Fly   266 PESTNGESYAKKLWDVLGKKNITPRPVKVHQPSATPASKIKGQNELIDEVHRNKHF----VYQAD 326
            |..:...|:.|.|.||..|....|.               |...|...||...|.|    :|.||
Mouse   271 PLRSFFSSHLKSLPDVRKKSLFLPE---------------KSNKEEKSEVVVWKEFDRAKLYTAD 320

  Fly   327 LEQAIRTVLHNEVSKVGEISGEKLLALQRFLAVLQRYNPLGANGHQLVSKLKDYVVQFNDQRLTG 391
            ||..:..:|..|::....::|.:|...:.|:.|:.:..|    |...|.||.:.:.::    |..
Mouse   321 LESGLHYLLRVELAAHRSLAGAQLKTFRDFVTVVAKLFP----GRPAVKKLLETLQEW----LAN 377

  Fly   392 SQFEE-------ELKRLEAHLSPVYSSNH--FVGCVGSSPRLRGFSCSLWTLFHFMTVQAANNEE 447
            ...::       :|...:..:|.::.::|  :|||.||...|||:.||||.|||.:||||:.:.|
Mouse   378 LPLDKIPYNAILDLVNNKMQISGIFLTSHVKWVGCQGSRLELRGYPCSLWKLFHTLTVQASTHPE 442

  Fly   448 T-------QDPLEVLQAMHGYIKNFFGCTECSEHFQAMASRRKIWSVPNKEEAVLWLWAAHNEVN 505
            .       ..|..||||:..||:.||||.||.|||:.|| :..:.||...::||||||..||.||
Mouse   443 ALAGTGFEGHPQAVLQAIRRYIRTFFGCKECGEHFEEMA-KESMDSVKTPDQAVLWLWRKHNMVN 506

  Fly   506 QRLAGDATEDPEFPKKQFPAPESCNECYRTPVSKSENLEIEWNKDAVLGFLKNIHN-PQFVSRYG 569
            .||||..:|||:|||..:|.|:.|..|:    .:.:.|: .||:..||.|||..:: ...|..|.
Mouse   507 SRLAGHLSEDPKFPKVPWPTPDLCPACH----EEIKGLD-SWNEGQVLLFLKQHYSRDNLVDAYS 566

  Fly   570 V-------------QREE---------------------------------LLHPTADKMRQKRQ 588
            |             ::||                                 .||...|...|..|
Mouse   567 VDQGSPGEWEAQGREQEEGKGLNPSGKSWRHHDTGSLRPPHILGPRTDLSKSLHHRLDLRLQSPQ 631

  Fly   589 --------------ISSVFTDMDMRMGMLLYAFCIVMMVLAFKLFAFKGYRKK 627
                          :...|:.:||.:.::||....:.:::.:..|..:..|.|
Mouse   632 GPQALKEAKAVVPFLGVGFSSLDMSLCVVLYVASSLFLMIMYFFFRVRSKRWK 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox1	NP_001286383.1	PDI_a_QSOX	49..162	CDD:239290	36/114 (32%)
Qsox1	NP_001286383.1	Evr1_Alr	430..521	CDD:282612	50/97 (52%)
Qsox2	NP_001289885.1	PDI_a_QSOX	55..168	CDD:239290	41/130 (32%)
		Evr1_Alr	425..522	CDD:282612	50/97 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..607		2/38 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835880
Domainoid	1	1.000	111	1.000	Domainoid score	I6231
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3019
Isobase	1	0.950	-	0	Normalized mean entropy	S4773
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm8738
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3816
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750