DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox1 and QSOX2

DIOPT Version :9

Sequence 1:	NP_001286383.1	Gene:	Qsox1 / 36464	FlyBaseID:	FBgn0033814	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_859052.3	Gene:	QSOX2 / 169714	HGNCID:	30249	Length:	698	Species:	Homo sapiens

Alignment Length:	733	Identity:	198/733 - (27%)
Similarity:	321/733 - (43%)	Gaps:	157/733 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IASAGVPLPRY------EALLKQQSPPS-----------------DPTLG----LYDDGDKVIRL 54
            :|:||..:.|.      .||..::|||.                 .|..|    ||..|:..:
Human     1 MAAAGAAVARSPGIGAGPALRARRSPPPRAARLPRLLVLLAAAAVGPGAGGAARLYRAGEDAV-- 63

  Fly    55 SVDNFNATVLDQN--RGA--------LVEFYNTYCGHCRRFAPTYKSVAEHLLPWSEVLIVAAID 109
                   .|||..  |||        ||:||:::||||..:|||::::|..:..|:..:.|||:|
Human    64 -------WVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALD 121

  Fly   110 CAAEENNGICRNYEVMGYPTLRYLGPGFQPGPQHY--GQSLHTQDKNEIREILAGMV-AAENLTS 171
            |..|:|..:|.:|::..|||.||    |:...:.:  |::....|: |:|.:...|: ..:|.|.
Human   122 CMEEKNQAVCHDYDIHFYPTFRY----FKAFTKEFTTGENFKGPDR-ELRTVRQTMIDFLQNHTE 181

  Fly   172 SHNNSYWPNFHYLTENDSASSLFEGLSSATEYVAVVHEPENTTLGVEVALFMTQWPAVRVRRVID 236
            .......|....:..:|..|.|.   :..:.|||:|.|..::.||.||.|.:..:.::.|.|.:|
Human   182 GSRPPACPRLDPIQPSDVLSLLD---NRGSHYVAIVFESNSSYLGREVILDLIPYESIVVTRALD 243

  Fly   237 PAVAAKFKIDPTNLPLSLV----DRKGEITAYAPESTNGESYAKKLWDVLGKKNITPRPVKVHQP 297
            ...|...|:..:::|...:    ...|.|....|......||.|.|.||  :|...|.|.|.|:
Human   244 GDKAFLEKLGVSSVPSCYLIYPNGSHGLINVVKPLRAFFSSYLKSLPDV--RKKSLPLPEKPHK- 305

  Fly   298 SATPASKIKGQNELIDEVHRNKHFVYQADLEQAIRTVLHNEVSKVGEISGEKLLALQRFLAVLQR 362
                    :..:|::.....:|..:|..|||..:..:|..|::....::|.:|..|:.|:.||.:
Human   306 --------EENSEIVVWREFDKSKLYTVDLESGLHYLLRVELAAHKSLAGAELKTLKDFVTVLAK 362

  Fly   363 YNPLGANGHQLVSKLKDYVVQFNDQRLTGSQFEEELKRLEAHLSPVYSSNH--FVGCVGSSPRLR 425
            ..|......:|:..|::::......|:..:.. .:|...:..:|.::.:||  :|||.||...||
Human   363 LFPGRPPVKKLLEMLQEWLASLPLDRIPYNAV-LDLVNNKMRISGIFLTNHIKWVGCQGSRSELR 426

  Fly   426 GFSCSLWTLFHFMTVQAANNEET-------QDPLEVLQAMHGYIKNFFGCTECSEHFQAMASRRK 483
            |:.||||.|||.:||:|:.:.:.       .||..|||.|..|:..||||.||.|||:.|| :..
Human   427 GYPCSLWKLFHTLTVEASTHPDALVGTGFEDDPQAVLQTMRRYVHTFFGCKECGEHFEEMA-KES 490

  Fly   484 IWSVPNKEEAVLWLWAAHNEVNQRLAGDATEDPEFPKKQFPAPESCNECYRTPVSKSENLEIE-- 546
            :.||...::|:||||..||.||.||||..:|||.|||.|:|.|:.|..|:.         ||:
Human   491 MDSVKTPDQAILWLWKKHNMVNGRLAGHLSEDPRFPKLQWPTPDLCPACHE---------EIKGL 546

  Fly   547 --WNKDAVLGFLKNIH-NPQFVSRY---------------GVQRE-------------------- 573
              |::..||.|||..: ....:..|               |.:.|
Human   547 ASWDEGHVLTFLKQHYGRDNLLDTYSADQGDSSEGGTLARGEEEEKRLTPPEVSHGDRDTQSVRP 611

  Fly   574 -----------ELLHPTADKMRQK-------RQISSV-------FTDMDMRMGMLLYAFCIVMMV 613
                       |.||.:.|...|.       :::...       |:.:||.:.::||....:.::
Human   612 PGALGPRPALPESLHHSLDGKLQSLDGPGAHKEVGGAAPFLGVDFSSLDMSLCVVLYVASSLFLM 676

  Fly   614 LAFKLFAFKGYRKKPYGH 631
            :.:..|..:..|.|...|
Human   677 VMYFFFRVRSRRWKVKHH 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox1	NP_001286383.1	PDI_a_QSOX	49..162	CDD:239290	38/124 (31%)
Qsox1	NP_001286383.1	Evr1_Alr	430..521	CDD:282612	47/97 (48%)
QSOX2	NP_859052.3	PDI_a_QSOX	61..174	CDD:239290	39/126 (31%)
		Evr1_Alr	431..527	CDD:282612	46/96 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..624		3/53 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145808
Domainoid	1	1.000	78	1.000	Domainoid score	I8795
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3076
Isobase	1	0.950	-	0	Normalized mean entropy	S4773
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm8504
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3816
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750