DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox1 and Qsox1

DIOPT Version :9

Sequence 1:	NP_001286383.1	Gene:	Qsox1 / 36464	FlyBaseID:	FBgn0033814	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001020116.1	Gene:	Qsox1 / 104009	MGIID:	1330818	Length:	748	Species:	Mus musculus

Alignment Length:	549	Identity:	181/549 - (32%)
Similarity:	277/549 - (50%)	Gaps:	75/549 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LYDDGDKVIRLSVDNFNATVLDQNRGALVEFYNTYCGHCRRFAPTYKSVAEHLLPWSEVLIVAAI 108
            ||...|.:..|..|:...|||..:....|||:.::||||..||||:|.:|..:..|...|.:|.:
Mouse    38 LYSSSDPLTLLDADSVRPTVLGSSSAWAVEFFASWCGHCIAFAPTWKELANDVKDWRPALNLAVL 102

  Fly   109 DCAAEENNGICRNYEVMGYPTLRYLGPGFQPGPQHYGQSLHTQDKNEIREILAGMVAAENLTSSH 173
            |||.|.|:.:||.:.:.|:||:|:.....:.|.   |.:|.....| ::.:...::.|   ..||
Mouse   103 DCAEETNSAVCREFNIAGFPTVRFFQAFTKNGS---GATLPGAGAN-VQTLRMRLIDA---LESH 160

  Fly   174 NNSYWPNF-------------HYLTENDSASSLFEGLSSATEYVAVVHEPENTTLGVEVALFMTQ 225
            .:: ||..             .:.|.|.:            :|:|:|.|.|::.||.||.|.::|
Mouse   161 RDT-WPPACPPLEPAKLNDIDGFFTRNKA------------DYLALVFEREDSYLGREVTLDLSQ 212

  Fly   226 WPAVRVRRVIDPAVAAKFKIDPTNLP-LSLVDRKGEITAYAPESTNGESYAKKLWDVLGKKNITP 289
            :.||.||||::.......|...|:.| ..|:.|.|.::.......:...|...|..:.|.....|
Mouse   213 YHAVAVRRVLNTESDLVNKFGVTDFPSCYLLLRNGSVSRVPVLVESRSFYTSYLRGLPGLTRDAP 277

  Fly   290 RPVKVHQPSATPASKIKGQNELIDEVHRNKHFVYQADLEQAIRTVLHNEVSKVGEISGEKLLALQ 354
                  ..:|||.:..|....:.....|:|  :|.||||.|:..:|..||.|...:.|::|:||:
Mouse   278 ------PTTATPVTADKIAPTVWKFADRSK--IYMADLESALHYILRVEVGKFSVLEGQRLVALK 334

  Fly   355 RFLAVLQRYNPLGANGHQLVS----KLKDYVVQFNDQRLTGSQFEEEL--KRLEAHLSPVYSSNH 413
            :|:|||.:|.|    |..||.    .:.|::.:...:|:..|.|:..|  ::.:|.|:   ...:
Mouse   335 KFVAVLAKYFP----GQPLVQNFLHSINDWLQKQQKKRIPYSFFKAALDSRKEDAVLT---EKVN 392

  Fly   414 FVGCVGSSPRLRGFSCSLWTLFHFMTVQA-----ANNEETQDPLEVLQAMHGYIKNFFGCTECSE 473
            :|||.||.|..|||.||||.||||:||||     |:.:|..|..||||||..|::.||||.:|::
Mouse   393 WVGCQGSEPHFRGFPCSLWVLFHFLTVQANRYSEAHPQEPADGQEVLQAMRSYVQFFFGCRDCAD 457

  Fly   474 HFQAMASRRKIWSVPNKEEAVLWLWAAHNEVNQRLAGDATEDPEFPKKQFPAPESCNECY----- 533
            ||:.||: ..:..|.:...|:||||.:||.||.||:|..:|||.|||.|:|..|.|:.|:
Mouse   458 HFEQMAA-ASMHQVRSPSNAILWLWTSHNRVNARLSGALSEDPHFPKVQWPPRELCSACHNELNG 521

  Fly   534 RTPVSKSENLEIEWNKDAVLGFLKNIHNP 562
            :.|:         |:..|.|.|||...:|
Mouse   522 QVPL---------WDLGATLNFLKAHFSP 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox1	NP_001286383.1	PDI_a_QSOX	49..162	CDD:239290	37/112 (33%)
Qsox1	NP_001286383.1	Evr1_Alr	430..521	CDD:282612	48/95 (51%)
Qsox1	NP_001020116.1	PDI_a_QSOX	43..155	CDD:239290	37/111 (33%)
		Evr1_Alr	409..501	CDD:282612	50/96 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..647
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835884
Domainoid	1	1.000	111	1.000	Domainoid score	I6231
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37690
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3019
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48718
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm8738
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	LDO	PTHR22897
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3816
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790