DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Qsox1 and qsox1

DIOPT Version :9

Sequence 1:	NP_001286383.1	Gene:	Qsox1 / 36464	FlyBaseID:	FBgn0033814	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001121836.1	Gene:	qsox1 / 100004382	ZFINID:	ZDB-GENE-030131-7019	Length:	778	Species:	Danio rerio

Alignment Length:	580	Identity:	185/580 - (31%)
Similarity:	286/580 - (49%)	Gaps:	63/580 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GLYDDGDKVIRLSVDNFNATVLDQNRGALVEFYNTYCGHCRRFAPTYKSVAEHLLPWSEVLIVAA 107
            |||...|:||.|:.:|.::|:.:.....|||||.|:||||..|:|.:||:|..:..|...:.:||
Zfish    42 GLYTASDQVIVLTPENVDSTLFNNTAALLVEFYATWCGHCIAFSPVWKSLARDIKEWKPAVDLAA 106

  Fly   108 IDCAAEENNGICRNYEVMGYPTLRYLGPGFQPGPQHYGQSLHTQDKNEIREILAGMVAAENLTSS 172
            ||||.|.|..:|.|:.:.|||::::.......|.:.......::|...:|:.:     .||| ..
Zfish   107 IDCANESNRKVCTNFGITGYPSIKFFHAYSSIGSRGLEVRGFSRDVRGLRQYI-----IENL-EL 165

  Fly   173 HNNSYWPN-------------FHYLTENDSASSLFEGLSSATEYVAVVHEPENTTLGVEVALFMT 224
            |..: ||.             .|:...|:            .:|:|:|.|.:.:.:|.||.|.:.
Zfish   166 HTEA-WPPACPPLETASEAEVHHFFPANN------------VKYLALVFENKKSYVGREVTLDLL 217

  Fly   225 QWPAVRVRRVIDPAVAAKFKIDPTNLP-LSLVDRKGEIT--AYAPESTNGESYA-KKLWDVL--G 283
            |:..:.||||:|.......:...|..| ..|.|..|.||  ....|:....||| ::|..|:  |
Zfish   218 QYENIAVRRVLDTETNLVSRFGVTEFPSCYLYDSSGNITRLKVLKEARTFYSYALQRLPGVVRTG 282

  Fly   284 KKNITPRPVKVHQPSATPASKIKGQNELIDEVHRNKHFVYQADLEQAIRTVLHNEVSKVGEISGE 348
            |          ||   ||.:::...:.|.:....||..||.:|||.|:...|..|:|....|||:
Zfish   283 K----------HQ---TPITELIKNSTLQEWRPFNKSRVYMSDLESALHYSLRVELSSHTSISGD 334

  Fly   349 KLLALQRFLAVLQRYNPLGANGHQLVSKLKDYVVQFNDQRLTGSQFEEELKRLEAHLSPVYSSN- 412
            .|:||::::.||.:|.|...:....:..:..::.......:..|.|.:.|..:......|....
Zfish   335 DLIALKKYINVLAKYFPGRPSVKSALQAVDSWLQSQKGTEIKYSDFRDVLDNVVQTSDAVLPEGV 399

  Fly   413 HFVGCVGSSPRLRGFSCSLWTLFHFMTVQAANNEET-QDPLEVLQAMHGYIKNFFGCTECSEHFQ 476
            .:|||.||..|.||:.|::|||||.:||||.....| .:|.|||.||.||:.:||||..|:.||:
Zfish   400 QWVGCQGSQARYRGYPCAVWTLFHVLTVQAKEMGSTVSEPQEVLLAMRGYVSSFFGCRPCATHFE 464

  Fly   477 AMASRRKIWSVPNKEEAVLWLWAAHNEVNQRLAGDATEDPEFPKKQFPAPESCNECYRTPVSKSE 541
            |||: ..:..|.:...||:|||:.||.||.|||||.:|||.|||.|:|:||.|..|:...:....
Zfish   465 AMAA-ESMDQVNSLSGAVIWLWSRHNRVNNRLAGDLSEDPHFPKIQWPSPELCPSCHGVTIIGDH 528

  Fly   542 NLEIEWNKDAVLGFLKNIHNPQFVSRYGVQREELLHPTADKMRQKRQISSVFTDMDMRMG 601
            |    |.||.|..||:|     :.|...:..:.|...|...::|:.::::...:.:...|
Zfish   529 N----WIKDEVPQFLQN-----YFSSSRILNDYLQDETQALIQQRNRLTAARMEKEAGRG 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox1	NP_001286383.1	PDI_a_QSOX	49..162	CDD:239290	38/112 (34%)
Qsox1	NP_001286383.1	Evr1_Alr	430..521	CDD:282612	48/91 (53%)
qsox1	NP_001121836.1	PDI_a_QSOX	48..161	CDD:239290	38/117 (32%)
qsox1	NP_001121836.1	Evr1_Alr	417..508	CDD:282612	48/91 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579254
Domainoid	1	1.000	115	1.000	Domainoid score	I5973
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37690
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2961
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm6583
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	LDO	PTHR22897
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770