DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fsd and TMEM183A

DIOPT Version :9

Sequence 1:	NP_610851.2	Gene:	fsd / 36463	FlyBaseID:	FBgn0033813	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_612400.3	Gene:	TMEM183A / 92703	HGNCID:	20173	Length:	376	Species:	Homo sapiens

Alignment Length:	272	Identity:	73/272 - (26%)
Similarity:	106/272 - (38%)	Gaps:	65/272 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 DIWFHISMHIDPEDVQTFALICKQTSRLVASRAFWRNLYRRHCTGATSGWNLNLPAELQLESIRN 128
            |||..::.:|.|||:..|:||||....:..:.|||..|||||.|     .:.:||..|:.||:.
Human   136 DIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYT-----LDASLPLRLRPESME- 194

  Fly   129 CKTRALKSLVIAALFHCHRPLKVRLELGYNLDWMLQRIFVSCFQT--HYQCLWIMCYKF-WNRQS 190
             |.|.|::.||.:|:|.:.|...|:...       ..|..|...|  :.:||...|.|. .|||.
Human   195 -KLRCLRACVIRSLYHMYEPFAARISKN-------PAIPESTPSTLKNSKCLLFWCRKIVGNRQE 251

  Fly   191 HEQDETETHTGEVVNDWE----------SLADDDATKLAP------TFCNPHEGVVLLVVICRH- 238
            ..              ||          .|.......|.|      ...||.:...||.|...:
Human   252 PM--------------WEFNFKFKKQSPRLKSKCTGGLQPPVQYEDVHTNPDQDCCLLQVTTLNF 302

  Fly   239 -FVPTSNHLAYGPQQQRYRLRATRELLCTDMRAKNLELDFAED---GCRNV----SVTVKHDRIE 295
             |:|    :..|.....:.:..:     ||||...:.|.|.:.   |.|.:    .|.|..|.:.
Human   303 IFIP----IVMGMIFTLFTINVS-----TDMRHHRVRLVFQDSPVHGGRKLRSEQGVQVILDPVH 358

  Fly   296 KYKVLPWWHPDF 307
            ..::..||||.:
Human   359 SVRLFDWWHPQY 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region
fsd	NP_610851.2	None
TMEM183A	NP_612400.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
TMEM183A	NP_612400.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..127
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159248
Domainoid	1	1.000	69	1.000	Domainoid score	I9660
eggNOG	1	0.900	-	-		E1_28JRD
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I5333
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50071
OrthoDB	1	1.010	-	-		D1290599at2759
OrthoFinder	1	1.000	-	-		FOG0007498
OrthoInspector	1	1.000	-	-		otm40948
orthoMCL	1	0.900	-	-		OOG6_109915
Panther	1	1.100	-	-	LDO	PTHR20988
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4873
SonicParanoid	1	1.000	-	-		X5628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800