DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex13 and PEX13

DIOPT Version :9

Sequence 1:	NP_610850.1	Gene:	Pex13 / 36462	FlyBaseID:	FBgn0033812	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_013292.1	Gene:	PEX13 / 850888	SGDID:	S000004181	Length:	386	Species:	Saccharomyces cerevisiae

Alignment Length:	410	Identity:	113/410 - (27%)
Similarity:	173/410 - (42%)	Gaps:	95/410 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DNNNLRSAVISDAPLLPPSSSIGVGVSSGGGYPPEAVLRTPYGNVRALPGPAQPPPLPQSPFQQT 67
            ::||..||..|...:||..:::.   |||           .||....:||
Yeast    44 ESNNSNSASESAPEVLPRPAALN---SSG-----------TYGESNTIPG--------------- 79

  Fly    68 QQYG--GFGSGYGGNNYGLGGYGGFNSGAFGYGGLGGFGSGLGSGFGSGYG--YGGGYGGGYGGG 128
             .||  .:|..|..|.|.:....|.:.|.:|||             ||.||  ||..||||||.|
Yeast    80 -IYGNSNYGIPYDNNPYSMNSIYGNSIGRYGYG-------------GSYYGNNYGSFYGGGYGAG 130

  Fly   129 FGGGYNRFGAMGENDAEQRFIYMAESSSRPAFQSIESLVSAIGNIASMLDSTFFALTSSFRAILG 193
            .|.|.|....:||             |::..||.||||:.|:...|.||:||:.|..:||..::.
Yeast   131 AGYGMNNGSGLGE-------------STKATFQLIESLIGAVTGFAQMLESTYMATHNSFFTMIS 182

  Fly   194 VATNFVRLRSVFAQFWTTFAIFRGLNWMYRKILYWLRLSNLD-PSSAAFKKAFAEALNENN---- 253
            ||..|..|:.:...|:..|||.:.|    :||||......|. |     .|.|||:....|
Yeast   183 VAEQFGNLKEMLGSFFGIFAIMKFL----KKILYRATKGRLGIP-----PKNFAESEGSKNKLIE 238

  Fly   254 --------GQARGAPNVPRKGNSPWPVLAFISFIFTAPYLIMKLL------GTVTNTAQEEARNP 304
                    |.........|:..|..|:|.|:..:|..|||:.|.:      ||: ..:|.....|
Yeast   239 DFQKFNDSGTINSNEKATRRKISWKPLLFFLMAVFGFPYLLNKFITKLQTSGTI-RASQGNGSEP 302

  Fly   305 AKWTAPIQTQAVYEFVARSPS-ELSLRAGQMLHVAPRDIQQTLNLLNTGWALATTNGQTSGIIPI 368
            ...:.....:|:|:||..:|. |::|:.|.::.:..:  :..|...:..|.:.|.||.. |.||.
Yeast   303 IDPSKLEFARALYDFVPENPEMEVALKKGDLMAILSK--KDPLGRDSDWWKVRTKNGNI-GYIPY 364

  Fly   369 SYVKSPQQMR--QEMQDQTK 386
            :|::..::.:  :.:.|:|:
Yeast   365 NYIEIIKRRKKIEHVDDETR 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex13	NP_610850.1	Peroxin-13_N	140..290	CDD:282008	49/162 (30%)
Pex13	NP_610850.1	SH3_PEX13_eumet	312..373	CDD:212798	17/61 (28%)
PEX13	NP_013292.1	Peroxin-13_N	140..283	CDD:397970	49/164 (30%)
PEX13	NP_013292.1	SH3_Pex13p_fungal	310..369	CDD:212705	17/61 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343433
Domainoid	1	1.000	61	1.000	Domainoid score	I2526
eggNOG	1	0.900	-	-		E1_KOG3875
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	114	1.000	Inparanoid score	I1348
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005709
OrthoInspector	1	1.000	-	-		oto99193
orthoMCL	1	0.900	-	-		OOG6_105516
Panther	1	1.100	-	-	LDO	PTHR19332
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.780