DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex13 and VAV2

DIOPT Version :9

Sequence 1:	NP_610850.1	Gene:	Pex13 / 36462	FlyBaseID:	FBgn0033812	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	XP_016870597.1	Gene:	VAV2 / 7410	HGNCID:	12658	Length:	896	Species:	Homo sapiens

Alignment Length:	177	Identity:	44/177 - (24%)
Similarity:	64/177 - (36%)	Gaps:	60/177 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 LRSVFAQFWTTFAIFRGLNWMYR-KILYWLRLSNLDPSS-AAFKKAFAEALNENNGQARGAPNVP 263
            |:..|.|..||      |.:.|: :.....|.|:..|:| |::..:|...  :....|...|:.|
Human   770 LKESFKQLDTT------LKYPYKSRERSASRASSRSPASCASYNFSFLSP--QGLSFASQGPSAP 826

  Fly   264 RKGNSPWPVLAFISFIFTAPYLIMKLLGTVTNTAQEEARNPAKWTAPIQTQAVYEFVARSPSELS 328
            .     |.|       ||.     :::||..                    |.|.|.||...|||
Human   827 F-----WSV-------FTP-----RVIGTAV--------------------ARYNFAARDMRELS 854

  Fly   329 LRAGQMLHVAPR---DIQQTLNLLNTGWALATTNGQTSGIIPISYVK 372
            ||.|.::.:..|   |         .||....|||:. |..|.:||:
Human   855 LREGDVVRIYSRIGGD---------QGWWKGETNGRI-GWFPSTYVE 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex13	NP_610850.1	Peroxin-13_N	140..290	CDD:282008	20/90 (22%)
Pex13	NP_610850.1	SH3_PEX13_eumet	312..373	CDD:212798	22/64 (34%)
VAV2	XP_016870597.1	CH_VAV2	2..120	CDD:409112
		RhoGEF	202..375	CDD:214619
		PH_Vav	389..534	CDD:269930
		C1_VAV2	537..594	CDD:410418
		SH3_VAV2_1	608..667	CDD:212913
		SH2_Vav2	685..787	CDD:198269	7/22 (32%)
		SH3_VAV2_2	837..894	CDD:212910	24/85 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030