DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex13 and Vav3

DIOPT Version :9

Sequence 1:	NP_610850.1	Gene:	Pex13 / 36462	FlyBaseID:	FBgn0033812	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_001365916.1	Gene:	Vav3 / 57257	MGIID:	1888518	Length:	875	Species:	Mus musculus

Alignment Length:	415	Identity:	85/415 - (20%)
Similarity:	123/415 - (29%)	Gaps:	139/415 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VDNNNLRSAVISDAPLLPPSS-SIGVGVSS---GGGYPPEAVLRTPYGNVRALPGPAQPPPLPQS 62
            |||.. |...:...|..||.. :.|:..:|   ..|.|...|:|...|.  ..||..:.|||...
Mouse   559 VDNCG-RVNSVEQGPFKPPEKRTNGLRRASRQVDPGLPKMQVIRNYTGT--PAPGLHEGPPLHIQ 620

  Fly    63 PFQQTQQYGGFGSG--YGGNNYGLGGYGGFNSGA----------FGYGGLGGFGSGLGSGFGSGY 115
            .....:...|....  :.|.|...|..|.|.|.|          ..|.....:.
Mouse   621 AGDTVELLRGDAHSVFWQGRNLASGEVGFFPSDAVKPSPCVPKPVDYSCQPWYA----------- 674

  Fly   116 GYGGGYGGGYGGGFGGGYNRFGAMGENDAEQRFIYMAESSSRPAFQSIESLVSAIG--------N 172
                                 |.|....||...|....|:.....::.||...||.        :
Mouse   675 ---------------------GPMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKH 718

  Fly   173 IASMLDSTFFALTSS--FRAILGVATNFVR--LRSVFAQFWTTFAIFRGLNWMYRKILYWLRLSN 233
            |..:....||.:..:  |::::.:...:..  |:..|....||      |.:.|:
Mouse   719 IKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTT------LQFPYK---------- 767

  Fly   234 LDPSSAAFKKAFAEALNENNGQARGAPNVPRKGNSPWPVLAFISFIFTAPY-------------L 285
             :|...|             || ||    .|.|||..|:....||:....|             |
Mouse   768 -EPEQPA-------------GQ-RG----NRTGNSSPPLFCGFSFVTPPDYSFVPPSSTPFWSVL 813

  Fly   286 IMKLLGTVTNTAQEEARNPAKWTAPIQTQAVYEFVARSPSELSLRAGQMLHVAPRDIQQTLNLLN 350
            ..|:||...                    |.|:|.||...||||..|.|:.:..:       :..
Mouse   814 SPKVLGIAI--------------------ARYDFCARDMRELSLLKGDMVKIYTK-------MSA 851

  Fly   351 TGWALATTNGQTSGIIPISYVKSPQ 375
            .||.....||:. |..|.:||:..:
Mouse   852 NGWWRGEVNGRV-GWFPSTYVEEDE 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex13	NP_610850.1	Peroxin-13_N	140..290	CDD:282008	34/174 (20%)
Pex13	NP_610850.1	SH3_PEX13_eumet	312..373	CDD:212798	19/60 (32%)
Vav3	NP_001365916.1	CH_VAV3	2..118	CDD:409113
		RhoGEF	193..369	CDD:238091
		PH_Vav	383..506	CDD:269930
		C1_VAV3	506..564	CDD:410419	3/5 (60%)
		SH3_VAV3_1	596..657	CDD:212914	16/62 (26%)
		SH2_Vav3	666..768	CDD:198270	21/150 (14%)
		SH3_VAV3_2	819..874	CDD:212911	20/82 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030