DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex13 and vav3b

DIOPT Version :9

Sequence 1:	NP_610850.1	Gene:	Pex13 / 36462	FlyBaseID:	FBgn0033812	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	XP_005163380.1	Gene:	vav3b / 559145	ZFINID:	ZDB-GENE-070912-251	Length:	853	Species:	Danio rerio

Alignment Length:	253	Identity:	52/253 - (20%)
Similarity:	85/253 - (33%)	Gaps:	75/253 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 GAMGENDAEQRFIYMAESSSRPAFQSIESLVSAIG----------NIASMLDSTFFALTSSFRAI 191
            |.|..:.||...:....|:....::|.||...||.          .:.:.....:.|.:.:|:.:
Zfish   662 GPMERHHAESELMERENSTYLVRYRSRESREYAISIKYNNDVKHLKVLTKEGCFYIAESRTFKNV 726

  Fly   192 LGVATNFVR--LRSVFAQFWTTFAI-FRGLNWMYRKILYWL-RLSNLDPSSAAFKKAFAEALNEN 252
            ||:...:.:  |:..|....||..: |:.|....|.....| .||.|.|:|..|
Zfish   727 LGLVEYYKQHSLKEGFRTLDTTLQVPFKELGTGLRTAAPVLCGLSVLSPTSYNF----------- 780

  Fly   253 NGQARGAPNVPRKGNSPWPVLAFISFIFTAPYLIMKLLGTVTNTAQEEARNPAKWTAPIQTQAVY 317
                     ||...:..|.||.            .::||...                    |.|
Zfish   781 ---------VPPSPSPFWSVLT------------PRVLGIAL--------------------ARY 804

  Fly   318 EFVARSPSELSLRAGQMLHVAPRDIQQTLNLLNTGWALATTNGQTSGIIPISYVKSPQ 375
            :|.:|...||||:.|.::.:..:        ...||.....||:. |..|.:||:..:
Zfish   805 DFSSRDTRELSLQVGDLVKIYIK--------CTNGWWKGEVNGRV-GWFPSTYVEEEE 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex13	NP_610850.1	Peroxin-13_N	140..290	CDD:282008	31/163 (19%)
Pex13	NP_610850.1	SH3_PEX13_eumet	312..373	CDD:212798	17/60 (28%)
vav3b	XP_005163380.1	CH	4..115	CDD:278723
		RhoGEF	194..368	CDD:279015
		PH_Vav	381..503	CDD:269930
		PH	406..499	CDD:278594
		C1	511..556	CDD:237996
		SH3	585..644	CDD:302595
		SH2	653..755	CDD:301589	19/92 (21%)
		SH3_VAV3_2	798..852	CDD:212911	18/82 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030