DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex13 and PEX13

DIOPT Version :9

Sequence 1:	NP_610850.1	Gene:	Pex13 / 36462	FlyBaseID:	FBgn0033812	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_002609.1	Gene:	PEX13 / 5194	HGNCID:	8855	Length:	403	Species:	Homo sapiens

Alignment Length:	426	Identity:	131/426 - (30%)
Similarity:	204/426 - (47%)	Gaps:	81/426 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SSSIGVGVSSGGGYPPEAVLRTPYGNVRALPGPAQPPPLPQSPFQQT---------QQYGGFGSG 76
            |:.:|..:.:..|.|  |:.|.|            ||.||: |.|||         ..|..|.||
Human    32 SADLGPTLMTRPGQP--ALTRVP------------PPILPR-PSQQTGSSSVNTFRPAYSSFSSG 81

  Fly    77 YGGNNYGLGGYGGFNSGAFGYGGLGGFGSGLGSGFGSGYGYGGGYGGGYGGGFGGGYNRFGAMGE 141
            ||.  ||...|||::..::||.||                               ||||...  :
Human    82 YGA--YGNSFYGGYSPYSYGYNGL-------------------------------GYNRLRV--D 111

  Fly   142 NDAEQRFIYMAESSSRPAFQSIESLVSAIGNIASMLDSTFFALTSSFRAILGVATNFVRLRSVFA 206
            :....||:..||.|||.|||||||:|.|..:::.|:|:||.|:.:||||:|.||.:|.||:..|.
Human   112 DLPPSRFVQQAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSFRAVLDVANHFSRLKIHFT 176

  Fly   207 QFWTTFAIFRGLNWMYRKILYWLRLSNLDPSSAAFKKAFAEALNENNGQARGAPNVPRKGNSPWP 271
            :.::.||:.|.:.::||::...|.|..    .:..:..:||  :|......||.:........||
Human   177 KVFSAFALVRTIRYLYRRLQRMLGLRR----GSENEDLWAE--SEGTVACLGAEDRAATSAKSWP 235

  Fly   272 VLAFISFIFTAPYLIMKLLGTVTNTAQEEARNPAKWTA----PIQTQAVYEFVARSPSELSLRAG 332
            :..|.:.|...||||.|||    :|..:|..:...|.:    .:..:|.|:|.|.|..|:|.|||
Human   236 IFLFFAVILGGPYLIWKLL----STHSDEVTDSINWASGEDDHVVARAEYDFAAVSEEEISFRAG 296

  Fly   333 QMLHVAPRDIQQTLNLLNTGWALATTNGQTSGIIPISYVK-SPQQMRQEMQDQTKPAQPQPELMN 396
            .||::|.::.|..:.    ||.||:.:|||:|:||.:||| ..::..::..:.:|.::.|....|
Human   297 DMLNLALKEQQPKVR----GWLLASLDGQTTGLIPANYVKILGKRKGRKTVESSKVSKQQQSFTN 357

  Fly   397 --LSAGAFASPPL-EQQMNYDFNLAAQQQAPLGPPS 429
              |:.||..:..| ||:..::.......:.|:.|.|
Human   358 PTLTKGATVADSLDEQEAAFESVFVETNKVPVAPDS 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex13	NP_610850.1	Peroxin-13_N	140..290	CDD:282008	53/149 (36%)
Pex13	NP_610850.1	SH3_PEX13_eumet	312..373	CDD:212798	27/61 (44%)
PEX13	NP_002609.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68		15/50 (30%)
		Peroxin-13_N	120..254	CDD:309283	51/139 (37%)
		Targeting to peroxisomes	145..233		28/93 (30%)
		Interaction with PEX19	175..196		6/20 (30%)
		SH3_PEX13_eumet	276..333	CDD:212798	26/60 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145968
Domainoid	1	1.000	93	1.000	Domainoid score	I7563
eggNOG	1	0.900	-	-		E1_KOG3875
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1967
Inparanoid	1	1.050	165	1.000	Inparanoid score	I4190
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46446
OrthoDB	1	1.010	-	-		D1085263at2759
OrthoFinder	1	1.000	-	-		FOG0005709
OrthoInspector	1	1.000	-	-		oto88935
orthoMCL	1	0.900	-	-		OOG6_105516
Panther	1	1.100	-	-	LDO	PTHR19332
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X5398
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800