DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex13 and Y37A1B.17

DIOPT Version :9

Sequence 1:	NP_610850.1	Gene:	Pex13 / 36462	FlyBaseID:	FBgn0033812	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_001076722.2	Gene:	Y37A1B.17 / 4926960	WormBaseID:	WBGene00044989	Length:	1523	Species:	Caenorhabditis elegans

Alignment Length:	441	Identity:	88/441 - (19%)
Similarity:	134/441 - (30%)	Gaps:	165/441 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PPEAVLRTPYGN--------VRALP-GPAQPPPLPQSPFQQTQQYGGFGSGYGGNNYGLGGYGGF 90
            |...|.:.|..|        .:.|| .||.|..:.|...||.||   ...|.||.||.|
Worm  1145 PTSLVPQAPAQNAQFDWNMAAKTLPLAPAPPMQVSQQAPQQQQQ---VQEGAGGANYNL------ 1200

  Fly    91 NSGAFGYGGLGGFGSGLGSGFGSGYGYGGGYGGGYGGGFGGGYNRFGAMGENDAEQRFIYMAESS 155
                    .|....|||     |...:|                                 |::|
Worm  1201 --------DLDNLFSGL-----STIDWG---------------------------------AKTS 1219

  Fly   156 SRPAFQSIESLVSAIGNIASMLDSTFFALTSSFRAI---LGV----------------------- 194
            :.|     ..|.|     .:.||:......|:||.:   .||
Worm  1220 TAP-----PPLYS-----NTPLDTATSPPVSAFRGVDFQTGVFNPNSLPDEAPPPLPVIVNPTRD 1274

  Fly   195 ---ATNFVRLRSVFAQFWTTFAIFRGLNWMYRKILYWLRLSNLDPSSAAFKKAFAEALNE--NNG 254
               :||||...:..|...:.|.                ..||   ||..|..:|.||.:.  :.|
Worm  1275 DPFSTNFVPNFAAAAPATSPFG----------------TASN---SSVQFPVSFDEAPSSMGSLG 1320

  Fly   255 QARGAPNVPRKGNSP------WPVLAFISFIFTAPYLIMKLLGTVTNTAQEEARNPAKWTAPIQT 313
            ...|:.|..|..::.      ||..:.:|                    :.::..|   ..|.:.
Worm  1321 LPTGSMNQKRSASAAAQPTNVWPTTSMMS--------------------RSDSPQP---LIPSRP 1362

  Fly   314 QAVYEFVARSPSELSLRAGQMLHVAPRDIQQTLNLLNTGWALATTNGQTSGIIPISYVKSPQQMR 378
            :...:.|..|.::.|.||.......|....|:|.:.:   |:.......:..:|..|..:||..|
Worm  1363 EPAVKNVYPSLNDGSARAPTFATTFPSQANQSLPMYS---AVPNDTMSMNYAMPPMYDTTPQSPR 1424

  Fly   379 QEMQDQTKPA--QPQP-------ELMNLSAGAFASPPLEQQMNYDFNLAAQ 420
            .::|.|.:||  ...|       :|.|.|..:.|..|:..|:..|::...|
Worm  1425 VQLQQQHQPAAYDTPPTIAPIYDQLPNESPASTAIRPVLCQVKVDYDFLPQ 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex13	NP_610850.1	Peroxin-13_N	140..290	CDD:282008	33/186 (18%)
Pex13	NP_610850.1	SH3_PEX13_eumet	312..373	CDD:212798	11/60 (18%)
Y37A1B.17	NP_001076722.2	SH3	169..224	CDD:214620
		SH3	250..306	CDD:214620
		RhoGEF	468..645	CDD:295373
		BAR	643..870	CDD:299863
		WWbp	<1387..1444	CDD:304964	14/59 (24%)
		SH3	1470..1522	CDD:302595	1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030