DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex13 and sif

DIOPT Version :9

Sequence 1:	NP_610850.1	Gene:	Pex13 / 36462	FlyBaseID:	FBgn0033812	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster

Alignment Length:	402	Identity:	78/402 - (19%)
Similarity:	143/402 - (35%)	Gaps:	114/402 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LRSAVISDAPL------LPPSSSIGVGVSSGGGYPPE--AVLRTPYGNVRALPGPAQPPPLPQSP 63
            :..|::||..:      |....|:.:.:.|....||:  .::|.....:.:|   ..|||....|
  Fly  1280 INGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSL---VCPPPPTDPP 1341

  Fly    64 FQQTQQYGGF---GSGYGGNNYGLGGYGGFNSGAFGYGGLGGFGSGLGSGFGSGYGYGGGYGGGY 125
            ....:...|.   ..|:.|.:..|......:|.|..:.......:.|..         ||.||..
  Fly  1342 VMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAV---------GGVGGVV 1397

  Fly   126 GGGFGGGYNRFGAMGENDAEQRFIYMAESSSRPAFQSIESLV----------SAIGNIASMLDST 180
            .||.|                    :|:.:||.:...||:|:          |..|::.|.:.:|
  Fly  1398 VGGLG--------------------VAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTT 1442

  Fly   181 FFALTSSFRAILGVATNFVRLRSVFAQFWTTFAIF-RGLNWMYRKILYWLR----LSNLDPSS-- 238
              |||.|.:     .|:..:||.|..:...|...: :.||.:....|..::    |||.:.::
  Fly  1443 --ALTPSRQ-----LTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALF 1500

  Fly   239 ------AAFKKAFAEALN------------ENNGQARGAPNVPRKGNSPWPVLAFI--SFIFTAP 283
                  ..|::.|.:.|.            |:.||.|.             ||..|  :|::...
  Fly  1501 GNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRN-------------VLFAIGSAFLYYVN 1552

  Fly   284 YLIMKLLGTVTNTAQEEARNPAKWTAPIQTQAVYEFV-ARSPSE--------LSLRAGQMLHVAP 339
            :..:......:::..::..:|.:     ...|:.||: ||:|.:        ..::..|.:...|
  Fly  1553 HFKLYSSFCASHSKAQKVLHPNE-----GNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYP 1612

  Fly   340 RDIQQTLNLLNT 351
            ..:||..||.:|
  Fly  1613 LLLQQMRNLTDT 1624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex13	NP_610850.1	Peroxin-13_N	140..290	CDD:282008	36/186 (19%)
Pex13	NP_610850.1	SH3_PEX13_eumet	312..373	CDD:212798	13/49 (27%)
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492	5/27 (19%)
		RhoGEF	1456..1647	CDD:238091	35/187 (19%)
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030