DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex13 and Plekhg3

DIOPT Version :9

Sequence 1:	NP_610850.1	Gene:	Pex13 / 36462	FlyBaseID:	FBgn0033812	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	XP_006515932.1	Gene:	Plekhg3 / 263406	MGIID:	2388284	Length:	1362	Species:	Mus musculus

Alignment Length:	233	Identity:	51/233 - (21%)
Similarity:	91/233 - (39%)	Gaps:	59/233 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 SNLDPSSAAFKKAFAEALNENNGQARGAP---NVPRKGN--SPW-----PVLAFISFIFTAP-YL 285
            |:.|..||..:...:||..:|   ..|:|   :||...|  |.|     |:..|.....|:| |.
Mouse    49 SSRDSHSAMEEPTGSEASAQN---GTGSPWDRHVPNSNNNSSGWLNMKGPLSPFNGRAGTSPAYH 110

  Fly   286 IMKLLGTVTNTAQEEARNPAKWTAPIQTQAVYEFVARS-----------------PSELSLRAG- 332
            .:..||.|....             ::|:.:|....||                 |.::|...|
Mouse   111 KLSYLGRVVREI-------------VETERMYVQDLRSIVEDYLLKIIDTPGLLKPEQVSALFGN 162

  Fly   333 -QMLHVAPRDIQQTLNLLNTG-WALATTNGQTSGIIPI------SYVKSPQQMRQEMQD--QTKP 387
             :.::.....:.:.|:..|:. .|:|:...:.|....|      :|..|...:.:.|||  |.|.
Mouse   163 IESIYALNSQLLRDLDSCNSDPVAVASCFVERSQEFDIYTQYCNNYPNSVAALTECMQDKQQAKF 227

  Fly   388 AQPQPELM--NLSAGAFASPPLEQQMNYDFNLAAQQQA 423
            .:.:.||:  :|..|::...|:::.:.|  :|..|:.|
Mouse   228 FRDRQELLQHSLPLGSYLLKPVQRVLKY--HLLLQEIA 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex13	NP_610850.1	Peroxin-13_N	140..290	CDD:282008	19/68 (28%)
Pex13	NP_610850.1	SH3_PEX13_eumet	312..373	CDD:212798	14/86 (16%)
Plekhg3	XP_006515932.1	RhoGEF	118..292	CDD:214619	30/161 (19%)
Plekhg3	XP_006515932.1	PH_PLEKHG1_G2_G3	274..417	CDD:270063
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030