DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex13 and PLEKHG3

DIOPT Version :9

Sequence 1:	NP_610850.1	Gene:	Pex13 / 36462	FlyBaseID:	FBgn0033812	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	XP_011534929.1	Gene:	PLEKHG3 / 26030	HGNCID:	20364	Length:	1391	Species:	Homo sapiens

Alignment Length:	500	Identity:	90/500 - (18%)
Similarity:	152/500 - (30%)	Gaps:	151/500 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PSSSIGVGVSSGGGYP---PEAVLRTPYGNVR------------ALPGPAQ-----PPPLPQSPF 64
            |...:...:|.....|   ||.|  .|.|:.|            .||||:|     |||:..:.|
Human   918 PKGLVRNSISRFNSLPRPDPEPV--PPVGSKRQVGSRPTSWALFELPGPSQAVKGDPPPISDAEF 980

  Fly    65 QQTQQYGGFGSGYGGNNYGLGGYGGFNSGAFGYGGLGGFGSGLGSGFGSGYGYGGGYGGGYGGGF 129
            :.:.:......|...:                                     ||..|.|.|.|.
Human   981 RPSSEIVKIWEGMESS-------------------------------------GGSPGKGPGQGQ 1008

  Fly   130 GGGY-----------NRFGAMGENDAEQRFIYMAESSSRPAFQSIESLVSAIGNIASMLDSTFFA 183
            ..|:           :..||:.|..|..    ..||||....:|...|...:..:...|.|
Human  1009 ANGFDLHEPLFILEEHELGAITEESATA----SPESSSPTEGRSPAHLARELKELVKELSS---- 1065

  Fly   184 LTSSFRAILGVATNFVRLRSVFAQFWTTFAIFRGLNWMYRKI-LYWLRLSNLDPSSAAFKKAFAE 247
             ::....:..:....|:|..|.    .:....|..|.:|:.. .|.||:.:..|..|.....:.:
Human  1066 -STQGELVAPLHPRIVQLSHVM----DSHVSERVKNKVYQLARQYSLRIKSNKPVMARPPLQWEK 1125

  Fly   248 ALNENNGQARGAPNVPRKGNSPW-------PVLAFISF-----------------------IFTA 282
            ...|.:|::...|.:..:...|.       |||:...:                       .|..
Human  1126 VAPERDGKSPTVPCLQEEAGEPLGGKGKRKPVLSLFDYEQLMAQEHSPPKPSSAGEMSPQRFFFN 1190

  Fly   283 PYLIMKLLGTVTNTAQEEARNPAKWTAPIQTQAVYEFVARSPS-ELSLRAG---------QMLHV 337
            |..:.:  .|.:...:..||:|...|.......|.|..::..| :.:.|||         ...|.
Human  1191 PSAVSQ--RTTSPGGRPSARSPLSPTETFSWPDVRELCSKYASRDEARRAGGGRPRGPPVNRSHS 1253

  Fly   338 APRDIQQTLNLLNTG--WALATTNGQTSGIIPISYVKSPQQMRQEMQDQTKPAQPQPEL------ 394
            .|.::.:.......|  .:|:|..|:..|    ...:||..:.|...|..:......:|
Human  1254 VPENMVEPPLSGRVGRCRSLSTKRGRGGG----EAAQSPGPLPQSKPDGGETLYVTADLTLEDNR 1314

  Fly   395 --MNLSAGAFASPPLEQQMNYDFNLAAQQQAPLGPPSTTSAVLGE 437
              :.:..|...||           .|..:::....||:..|:||:
Human  1315 RVIVMEKGPLPSP-----------TAGLEESSGQGPSSPVALLGQ 1348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex13	NP_610850.1	Peroxin-13_N	140..290	CDD:282008	30/180 (17%)
Pex13	NP_610850.1	SH3_PEX13_eumet	312..373	CDD:212798	13/72 (18%)
PLEKHG3	XP_011534929.1	RhoGEF	118..292	CDD:279015
		PH_PLEKHG1_G2_G3	274..417	CDD:270063
		PH	338..414	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030