DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dp and Tfdp1

DIOPT Version :9

Sequence 1:	NP_477039.1	Gene:	Dp / 36461	FlyBaseID:	FBgn0011763	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	XP_008769619.1	Gene:	Tfdp1 / 361178	RGDID:	1560344	Length:	410	Species:	Rattus norvegicus

Alignment Length:	387	Identity:	173/387 - (44%)
Similarity:	220/387 - (56%)	Gaps:	61/387 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 IPKTEAGTTYTTVSAQKTSG------------AGSGHYDLPLKGDRYVKFTPNPIKMKSKLHAIQ 143
            :||| .|.:...::.|...|            .||.|             |||       .|.:.
  Rat    47 LPKT-FGQSNVNITQQVVIGTPQRPAAANTIVVGSPH-------------TPN-------THFVS 90

  Fly   144 SNSLHSMSASSSSVQRKRKPDKAGKGLRHFSMKVCEKVEEKGKTTYNEVADDLVSEEMKNNAYDN 208
            .|.. |.|:..|:.:|.||.:|.|||||||||||||||:.||.|:||||||:||:|   .:|.||
  Rat    91 QNQT-SDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAE---FSAADN 151

  Fly   209 NC-------DQKNIRRRVYDALNVLMAINVISKDKKEIRWIGLPANSTETFLALEEENCQRRERI 266
            :.       ||||||||||||||||||:|:|||:||||:|||||.||.:....||.|..:|.|||
  Rat   152 HILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERI 216

  Fly   267 KQKNEMLREMIMQHVAFKGLVERNKRNESQG-VVPSPNASIQLPFIIVNTHKSTKINCSVTNDKS 330
            |||...|:|:|:|.:|||.||:||::.|.|. ..|.||:.|.||||||||.:.|.|:||::|||.
  Rat   217 KQKQSQLQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSISNDKF 281

  Fly   331 EYIFKFDKTFEMHDDIEVLKRMGFLLGLDKGECTPENIERVKSWVPPNLAKYVEAYGTGKTG--- 392
            ||:|.||.|||:|||||||||||...||:.|.|:.|:::..:|.||..|..||.....|..|
  Rat   282 EYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKVARSLVPKALEPYVTEMAQGSIGGVF 346

  Fly   393 ---------ENMYESDDEDNEFNGYLESANESQGFAQHSAQHTTDGEFKLEMDDDELDDDID 445
                     .....:.|..|..:|.|  |..|.|.....::..|...:..|.|||  |||.:
  Rat   347 VTTTGSTSNGTRLSASDLSNGADGML--ATSSNGSQYSGSRVETPVSYVGEDDDD--DDDFN 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dp	NP_477039.1	E2F_TDP	167..243	CDD:280479	57/82 (70%)
		coiled coil	248..294	CDD:271217	22/45 (49%)
		DP	255..388	CDD:285934	72/133 (54%)
Tfdp1	XP_008769619.1	E2F_TDP	113..193	CDD:396755	57/82 (70%)
		coiled coil	198..244	CDD:271217	22/45 (49%)
		DP	200..338	CDD:400917	72/137 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334526
Domainoid	1	1.000	145	1.000	Domainoid score	I4460
eggNOG	1	0.900	-	-		E1_KOG2829
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2884
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046304at2759
OrthoFinder	1	1.000	-	-		FOG0002399
OrthoInspector	1	1.000	-	-		otm45543
orthoMCL	1	0.900	-	-		OOG6_102647
Panther	1	1.100	-	-	O	PTHR12548
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1414
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800