DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dp and tfdp2

DIOPT Version :9

Sequence 1:	NP_477039.1	Gene:	Dp / 36461	FlyBaseID:	FBgn0011763	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_937851.1	Gene:	tfdp2 / 338204	ZFINID:	ZDB-GENE-030219-104	Length:	409	Species:	Danio rerio

Alignment Length:	431	Identity:	179/431 - (41%)
Similarity:	237/431 - (54%)	Gaps:	72/431 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ARNSGSASGIGNVGRMGAF-SQMGSQGQFIRLQDNGLS-IPKTEAGTTYTTVSA-------QKTS 109
            |...|:|:..|:   :.|| :|..|:|....|..:..| ..|...||..:.|.|       |:.|
Zfish     3 ANTIGAAALCGD---LKAFLNQNLSKGNISLLTPSSYSPANKITLGTVNSNVGAQMILSTPQRVS 64

  Fly   110 GAGSGHYDLPLKGDRYVKFTPN--PIKMKSKLHAIQSN---------------SLHS-----MSA 152
            .:|:.....|        |||:  |:.|.::.|..:.|               |.:|     .|:
Zfish    65 HSGNILIGSP--------FTPHTTPVAMVTQAHPPEGNEWTPGNKKRTHDYIDSYYSDRDGLCSS 121

  Fly   153 SSSSVQRKRKPDKAGKGLRHFSMKVCEKVEEKGKTTYNEVADDLVSE--------EMKNNAYDNN 209
            .|||.:|.::.||.|||||||||||||||::||.|:||||||:||:|        ...:..|
Zfish   122 DSSSSKRLKRADKNGKGLRHFSMKVCEKVQKKGTTSYNEVADELVAEFTHASSLMPADSQVY--- 183

  Fly   210 CDQKNIRRRVYDALNVLMAINVISKDKKEIRWIGLPANSTETFLALEEENCQRRERIKQKNEMLR 274
             ||||||||||||||||||:|:|||:||||||||||.||.:....||.|..:|.|||:||...|.
Zfish   184 -DQKNIRRRVYDALNVLMAMNIISKEKKEIRWIGLPTNSAQECRNLELEKQKRLERIRQKRAQLE 247

  Fly   275 EMIMQHVAFKGLVERNKRNESQGVVPSPNAS-IQLPFIIVNTHKSTKINCSVTNDKSEYIFKFDK 338
            |:|:|.||||.||:||:.:|:......|..| |||||||:||...|.|:||:::||.||:|.||.
Zfish   248 ELILQQVAFKNLVQRNQASEASSRSSPPAGSVIQLPFIILNTDVRTVIDCSISSDKCEYLFNFDN 312

  Fly   339 TFEMHDDIEVLKRMGFLLGLDKGECTPENIERVKSWVPPNLAKYVEAYGTGKTGENMYESDDEDN 403
            |||:|||:|:|||||..|||:.|.|:|:|:...||.||.:|..|:.......|...:
Zfish   313 TFEIHDDVEILKRMGMSLGLENGTCSPQNLTLAKSLVPKSLEAYITNMARNSTRTPL-------- 369

  Fly   404 EFNGYLESANESQGFAQHSAQHT-TDGEFKLEMDDDELDDD 443
                   |...|...:..|.... |...|. |.||::.|||
Zfish   370 -------SLTSSTALSHTSESRVLTPSSFN-EADDEDDDDD 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dp	NP_477039.1	E2F_TDP	167..243	CDD:280479	56/83 (67%)
		coiled coil	248..294	CDD:271217	22/45 (49%)
		DP	255..388	CDD:285934	69/133 (52%)
tfdp2	NP_937851.1	E2F_TDP	136..216	CDD:280479	56/83 (67%)
		coiled coil	221..267	CDD:271217	22/45 (49%)
		DP	223..362	CDD:285934	69/138 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573597
Domainoid	1	1.000	144	1.000	Domainoid score	I4552
eggNOG	1	0.900	-	-		E1_KOG2829
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I2969
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046304at2759
OrthoFinder	1	1.000	-	-		FOG0002399
OrthoInspector	1	1.000	-	-		otm25752
orthoMCL	1	0.900	-	-		OOG6_102647
Panther	1	1.100	-	-	LDO	PTHR12548
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1414
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.800