Protein Alignment Dp and E2F1

DIOPT Version :9

• Sequence 1: NP_477039.1
• Gene: Dp / 36461
• FlyBaseID: FBgn0011763
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_005216.1
• Gene: E2F1 / 1869
• HGNCID: 3113
• Length: 437
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 72/390 - (18%)
• Similarity: 129/390 - (33%)
• Gaps: 147/390 - (37%)

  Fly   132 PIKMKSKLHAIQSNSLHSMSASSSSVQRKRKPDKAGKGLRHFSMKVCEKVEEKGKTTYNEVADDL 196
            |:|.:..|   :::..:...:|..:..|.|.|   |||           |:..|:.:..|.:.:|
Human    87 PVKRRLDL---ETDHQYLAESSGPARGRGRHP---GKG-----------VKSPGEKSRYETSLNL 134

  Fly   197 VSE---EMKNNAYDNNCD-------QKNIRRRVYDALNVLMAINVIS-KDKKEIRWIG------- 243
            .::   |:.:::.|...|       .|..:||:||..|||..|.:|: |.|..|:|:|
Human   135 TTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTTVGV 199

  Fly   244 ------------------------LPANSTETFLALEEENCQRR-----ERIKQKNEMLREMIMQ 279
                                    :...:|:..|..|:.:.||.     :.::...:...:|:|
Human   200 GGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDSQRLAYVTCQDLRSIADPAEQMVM- 263

  Fly   280 HVAFKGLVERNKRNESQGVVPSPNASIQL-------------------------PFIIVNTHKST 319
                  :::.....:.|.|..|.|..|.|                         |...|.:.:..
Human   264 ------VIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPEETVGGISPGKTPSQEVTSEEEN 322

  Fly   320 KIN--------------CSVTNDKSEYIFKFDKTFEMHDDIEVLKRMGFLLGLDKGECTPENIER 370
            :..              .|:|.|.|:.:...::.       .:|.|||.|.       .|.:.:|
Human   323 RATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQE-------PLLSRMGSLR-------APVDEDR 373

  Fly   371 VKSWVPPNLAKYVEAYGTGKTGENMYESDDEDNEFNGYLESANESQGFAQHSAQH-TTDGEFKLE 434
            :...|               ..:::.|...||  |:|.|     .:.|...|..| ..|..|.||
Human   374 LSPLV---------------AADSLLEHVRED--FSGLL-----PEEFISLSPPHEALDYHFGLE 416

  Fly   435  434
            Human   417  416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dp	NP_477039.1	E2F_TDP	167..243	CDD:280479	24/86 (28%)
		coiled coil	248..294	CDD:271217	7/50 (14%)
		DP	255..388	CDD:285934	25/176 (14%)
E2F1	NP_005216.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..87		72/390 (18%)
		Cyclin A:CDK2 binding. /evidence=ECO:0000269|PubMed:8033208	67..108		4/23 (17%)
		Interaction with BIRC2/c-IAP1. /evidence=ECO:0000269|PubMed:21653699	89..191		29/118 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..128		9/40 (23%)
		E2F_TDP	129..192	CDD:280479	19/62 (31%)
		Leucine-zipper	153..174		6/20 (30%)
		DEF box	158..194		15/35 (43%)
		Required for interaction with TRIM28. /evidence=ECO:0000269|PubMed:17704056	192..382		28/225 (12%)
		Dimerization. /evidence=ECO:0000255	195..284		11/95 (12%)
		E2F_DD	202..301	CDD:271137	13/105 (12%)
		coiled coil	202..236	CDD:271137	2/33 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..349		6/48 (13%)
		Transactivation	368..437		16/71 (23%)
		RB1 binding. /evidence=ECO:0000269|PubMed:12598654	409..426		4/8 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910