DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dp and AgaP_AGAP012461

DIOPT Version :9

Sequence 1:	NP_477039.1	Gene:	Dp / 36461	FlyBaseID:	FBgn0011763	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	XP_309901.3	Gene:	AgaP_AGAP012461 / 1271158	VectorBaseID:	AGAP012461	Length:	584	Species:	Anopheles gambiae

Alignment Length:	375	Identity:	162/375 - (43%)
Similarity:	235/375 - (62%)	Gaps:	44/375 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 IPKTEAGTTYTTVSAQKTSGAGSGHYDLPLKGDRYVKFTPNPIKMKSKLHAIQSN--------SL 147
            |...|.|.|.....::..:.:|:   |.|    .|::     :...|.:.::|||        ..
Mosquito   228 IVSLEKGVTKIATISKSYNESGN---DSP----PYLQ-----LSCASAVKSLQSNHSYKDHQQQQ 280

  Fly   148 HSMSASSSSVQ------RKRKPDKAGKGLRHFSMKVCEKVEEKGKTTYNEVADDLVSEEMKNN-- 204
            ||.|..:|:.|      |::|.||||:|||||||||||||:.||.|||||||::||:||.:|:
Mosquito   281 HSYSKKTSTSQIHTPASRRQKADKAGRGLRHFSMKVCEKVKAKGTTTYNEVANELVAEETQNHNQ 345

  Fly   205 -AYDNNCDQKNIRRRVYDALNVLMAINVISKDKKEIRWIGLP-ANSTETFLALEEENCQRRERIK 267
             ......||||||||||||||||||:.:|||:||||||.||| :|:.:....||:||.:.|.||:
Mosquito   346 GVDPGTYDQKNIRRRVYDALNVLMAMKIISKEKKEIRWHGLPTSNTLQECEELEKENEKARRRIE 410

  Fly   268 QKNEMLREMIMQHVAFKGLVERNKRNESQGVVPSPNASIQLPFIIVNTHKSTKINCSVTNDKSEY 332
            .|.:.|.:::.||||.|.|:.|||.||.:|::|:||:::|||||||||.:.:.|||:::||||||
Mosquito   411 IKQQQLLDLVQQHVALKSLIARNKANEERGLIPNPNSAVQLPFIIVNTDRKSNINCNISNDKSEY 475

  Fly   333 IFKFDKTFEMHDDIEVLKRMGFLLGLDKGECTPENIERVKSWVPPNLAKYVEAYGTGKTGENMYE 397
            .|||:.:||:|||:::|||:|..|.|:||..:..:::::||.||..:.||::|||.|      :|
Mosquito   476 SFKFEDSFEIHDDVQILKRIGLSLALEKGHYSETDLKKIKSMVPKAVEKYIDAYGLG------FE 534

  Fly   398 SDDEDN-EFNGYLESANESQGFAQH---SAQHTT----DGEFKLEMDDDE 439
            .||.|: |.:......:.....:..   :...||    |.|.|.|.|:|:
Mosquito   535 QDDVDDWEMSSLYNGPDNDDSLSTQDMLAFNDTTNDMLDDEMKFEDDEDD 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dp	NP_477039.1	E2F_TDP	167..243	CDD:280479	55/78 (71%)
		coiled coil	248..294	CDD:271217	18/45 (40%)
		DP	255..388	CDD:285934	66/132 (50%)
AgaP_AGAP012461	XP_309901.3	E2F_TDP	306..385	CDD:280479	55/78 (71%)
AgaP_AGAP012461	XP_309901.3	DP	404..527	CDD:285934	60/122 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	153	1.000	Domainoid score	I8851
eggNOG	1	0.900	-	-		E1_KOG2829
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I5243
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046304at2759
OrthoFinder	1	1.000	-	-		FOG0002399
OrthoInspector	1	1.000	-	-		oto108778
Panther	1	1.100	-	-	LDO	PTHR12548
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1414
TreeFam	1	0.960	-	-
	11	10.930