DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fsn and Spsb3

DIOPT Version :9

Sequence 1:	NP_610849.1	Gene:	Fsn / 36460	FlyBaseID:	FBgn0043010	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	XP_006525228.1	Gene:	Spsb3 / 79043	MGIID:	1891471	Length:	525	Species:	Mus musculus

Alignment Length:	233	Identity:	62/233 - (26%)
Similarity:	89/233 - (38%)	Gaps:	66/233 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DENSDVWRWHCLNKLPKESLKSDLLASVSTYKTKLRAYFHAWSPNDCSRNVYIKPNGFTLHRNPV 106
            ||:.| |.|..|||      .|..|.|....|..    ||  ....|
Mouse   246 DEDFD-WVWDDLNK------SSATLLSCDNRKVS----FH--MEYSC------------------ 279

  Fly   107 AQSTDAARGKIGFRHGRHTWEVIWEGPL-GTVAVIGISTKEAALQ--CHGYVALLGSDDQS---- 164
              .|.|.||......|:|.||:....|: ||..::||.|.:..|.  .|.:.:|||.|:.|
Mouse   280 --GTAAIRGTKELGDGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLS 342

  Fly   165 ----------WGWN----------LVENHLLHNGDMQGSYPLLNNAPKYQVGERIRVILDCEDNT 209
                      |||.          |:...|.|.|| :.|:     :.::..|..|.|.||....|
Mouse   343 YTGRCCLGHGWGWQYSRPPRITPLLLAGLLHHKGD-KTSF-----SSRFGQGSIIGVHLDTWHGT 401

  Fly   210 LSFEKNYEFLGVAFRGLPDKKLYPTVSAVYGNTEVSMV 247
            |:|.||.:.:|||...|.:::.||.|.:....:.:.::
Mouse   402 LTFFKNRKCIGVAATRLQNRRFYPMVCSTAAKSSMKVI 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fsn	NP_610849.1	F-box-like	13..54	CDD:289689	5/11 (45%)
Fsn	NP_610849.1	SPRY_Fbox	81..255	CDD:293964	49/194 (25%)
Spsb3	XP_006525228.1	SPRY_SOCS3	250..457	CDD:293936	60/229 (26%)
Spsb3	XP_006525228.1	SOCS	447..483	CDD:383010
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3953
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810