DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fsn and Spsb2

DIOPT Version :9

Sequence 1:	NP_610849.1	Gene:	Fsn / 36460	FlyBaseID:	FBgn0043010	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_001009660.1	Gene:	Spsb2 / 297592	RGDID:	1310854	Length:	264	Species:	Rattus norvegicus

Alignment Length:	175	Identity:	80/175 - (45%)
Similarity:	103/175 - (58%)	Gaps:	7/175 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 HAWSPNDCSRNVYIKPNGFTLHRNPVAQSTDAARGKIGFRHGRHTWEVIWEGPL---GTVAVIGI 142
            |.|:|.|||.|:.:|..|....|.|||||||..|||.|:..|.|.||:.|  ||   ||.||:|:
  Rat    46 HGWNPKDCSENIDVKEGGLCFERRPVAQSTDGVRGKRGYSRGLHAWEISW--PLEQRGTHAVVGV 108

  Fly   143 STKEAALQCHGYVALLGSDDQSWGWNLVENHLLH--NGDMQGSYPLLNNAPKYQVGERIRVILDC 205
            :|..|.||...|.|||||:.:||||::....|.|  .|.....||......:..|.||:.|:||.
  Rat   109 ATALAPLQADHYAALLGSNSESWGWDIGRGKLYHQSKGLEAPQYPAGPQGEQLVVPERLLVVLDM 173

  Fly   206 EDNTLSFEKNYEFLGVAFRGLPDKKLYPTVSAVYGNTEVSMVYLG 250
            |:.||.:.....:||.|||||..:.|||:||||:|..:|.:.|||
  Rat   174 EEGTLGYSIGGTYLGPAFRGLKGRTLYPSVSAVWGQCQVRIRYLG 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fsn	NP_610849.1	F-box-like	13..54	CDD:289689
Fsn	NP_610849.1	SPRY_Fbox	81..255	CDD:293964	80/175 (46%)
Spsb2	NP_001009660.1	SPRY_SOCS1-2-4	46..217	CDD:293963	77/172 (45%)
Spsb2	NP_001009660.1	SOCS_SSB2	223..264	CDD:239689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3953
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810