DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fsn and Spsb4

DIOPT Version :9

Sequence 1:	NP_610849.1	Gene:	Fsn / 36460	FlyBaseID:	FBgn0043010	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_660116.1	Gene:	Spsb4 / 211949	MGIID:	2183445	Length:	273	Species:	Mus musculus

Alignment Length:	174	Identity:	82/174 - (47%)
Similarity:	114/174 - (65%)	Gaps:	5/174 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 HAWSPNDCSRNVYIKPNG-FTLHRNPVAQSTDAARGKIGFRHGRHTWEVIWEG-PLGTVAVIGIS 143
            |||:|.|.|.||::|.:. .|.||:|||||||..|||:|...|.|.|::.|.. ..||.||:|::
Mouse    54 HAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQIHWPARQRGTHAVVGVA 118

  Fly   144 TKEAALQCHGYVALLGSDDQSWGWNLVENHLLHNGDMQG--SYP-LLNNAPKYQVGERIRVILDC 205
            |..|.|...||.||:|||.:||||:|..:.|.|:|..:.  :|| .|.....:.:.:.:.|:||.
Mouse   119 TARAPLHSVGYTALVGSDSESWGWDLGRSRLYHDGKNRPGVAYPAFLGPDEAFALPDSLLVVLDM 183

  Fly   206 EDNTLSFEKNYEFLGVAFRGLPDKKLYPTVSAVYGNTEVSMVYL 249
            ::.||||..:.::||||||||..|||||.||||:|:.||:|.|:
Mouse   184 DEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYI 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fsn	NP_610849.1	F-box-like	13..54	CDD:289689
Fsn	NP_610849.1	SPRY_Fbox	81..255	CDD:293964	82/174 (47%)
Spsb4	NP_660116.1	SPRY_SOCS1-2-4	54..227	CDD:293963	81/172 (47%)
Spsb4	NP_660116.1	SOCS	232..273	CDD:413360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3953
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810