DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and SLC22A13

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_004247.2	Gene:	SLC22A13 / 9390	HGNCID:	8494	Length:	551	Species:	Homo sapiens

Alignment Length:	583	Identity:	175/583 - (30%)
Similarity:	280/583 - (48%)	Gaps:	85/583 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANWV 79
            |..:|.|||:|||||.:..:|:|:....:.....::||......:.|.|
Human     4 FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAV---------------- 52

  Fly    80 SIAVPGSWSKRGHFTPSTCERFVAN-----GDHLESS---SDPWSAWPLDQCFAENFTTETERCN 136
                  :|.|...|..|..|:.|.:     ..|.|..   ..|.:...|....:..| .||:.|:
Human    53 ------AWVKNHTFNLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRF-NETQPCD 110

  Fly   137 Q-FVYGSSE-RTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVF 199
            . :.|..:. .::..::.|.|.....| ....::..|||:|||.:.|.|.||.|||...|..::.
Human   111 MGWEYPENRLPSLKNEFNLVCDRKHLK-DTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLL 174

  Fly   200 MALTGVAQAL--SWDYISFLFFALLNAVGTSGVYPLAF---IIGVEMVGPRKREMSSIVLNYFYA 259
            ..|.|:|.|.  |::    |:.||..||.|: |..|:|   .:..|.|||..|..:.::....::
Human   175 FTLIGLATAFVPSFE----LYMALRFAVATA-VAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFS 234

  Fly   260 VGEALL-GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNR 323
            :|:.:| ||:....:||.||:..:.|.|:...|||.:|||.||||.|.|.::|..:|::||.|||
Human   235 LGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNR 299

  Fly   324 RDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVN 388
            |.:|.|||    .|.:..:||...:                ..::.|...|.....|:..:|.|:
Human   300 RKLSPELM----NQLVPEKTGPSGN----------------ALDLFRHPQLRKVTLIIFCVWFVD 344

  Fly   389 AIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGF 453
            ::.||||||.......:.||...:...||:|....:...::||||:.:..|:|:|..:.|:...|
Human   345 SLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIF 409

  Fly   454 VTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGV 518
                    ||....|           :|..|.:|||:...::|.:.|.::||:.||::|..|:|:
Human   410 --------IPADLPV-----------VVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGL 455

  Fly   519 MSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIALG 581
            :..|:|.|.:|.|.|.||..|:..||:|::|:|.:|||||..|||||..:.|.||::: :.||
Human   456 VGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQD-LELG 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	167/565 (30%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	118/380 (31%)
SLC22A13	NP_004247.2	2A0119	12..510	CDD:273328	167/565 (30%)
		MFS	139..500	CDD:119392	132/404 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551		2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.930