Protein Alignment CG4630 and SLC22A6

DIOPT Version :9

• Sequence 1: NP_001260948.1
• Gene: CG4630 / 36458
• FlyBaseID: FBgn0033809
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_004781.2
• Gene: SLC22A6 / 9356
• HGNCID: 10970
• Length: 563
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 163/574 - (28%)
• Similarity: 278/574 - (48%)
• Gaps: 70/574 - (12%)

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGAN-W 78
            |:|:|.::|..||||:....|:.||:|..|:::....|||..||:.|..|     .||....| .
Human     3 FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPP-----ADANLSKNGG 62

  Fly    79 VSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCNQ-FVYGS 142
            :.:.:|.  .::|.  |.:|.||         :|..|.. |.......|.|..||.|.. ::|.:
Human    63 LEVWLPR--DRQGQ--PESCLRF---------TSPQWGL-PFLNGTEANGTGATEPCTDGWIYDN 113

  Fly   143 S--ERTIVQQWGLQCPEN-LWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMALTG 204
            |  ..|||.:|.|.|... |.:||  .:::..|:::|..:.||||||.||:.:.:...:..|::|
Human   114 STFPSTIVTEWDLVCSHRALRQLA--QSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSG 176

  Fly   205 VAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALL-GLS 268
            ...|.:.::..:..|.||:.:..:|:......:.||.:....|.....::.|.|::|:.|| |::
Human   177 TCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVA 241

  Fly   269 VFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVN-RRD----ISV 328
            ..:|.||.|||.:|.|......|.|...||.||..:..|.:.....::|.|::| :|:    :|:
Human   242 YAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSM 306

  Fly   329 ELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYY 393
            |::.:..|:||....||                 .:..|:.|...|...:..|.::|...:..||
Human   307 EVLRASLQKELTMGKGQ-----------------ASAMELLRCPTLRHLFLCLSMLWFATSFAYY 354

  Fly   394 GLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQ 458
            ||.::......:.||...:...|::|...:.:|.:...|||.|...:|||..|..:.:|.:...|
Human   355 GLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQ 419

  Fly   459 GDWIPCQTGVESRHSWSCANWLVVT-LFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTF 522
            .                    :|.| |.::||..:.:||..|:.:|.|:.||:||..|:|:.||.
Human   420 S--------------------IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTM 464

  Fly   523 ARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576
            ||.|::::|.|.:.|..|..:||.::|.:.:.|..:::|||||..:.|||||::
Human   465 ARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQD 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	157/561 (28%)
		MFS	158..533	CDD:119392	101/382 (26%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	157/561 (28%)
		MFS	135..505	CDD:119392	108/408 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..563

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153805
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.960