DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4630 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	173/571 - (30%)
Similarity:	265/571 - (46%)	Gaps:	72/571 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LDFDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGAN 77
            :.|.:||..:|..|.||..:..|:.||||..|.::|..:|||.:|.:.|..|.     :|..|.
  Rat     1 MTFSEILDRVGSMGPFQYLHVTLLALPVLGIANHNLLQIFTATTPVHHCRPPP-----NASIGP- 59

  Fly    78 WVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTE-TERC-NQFVY 140
            ||....|..       .|..|.|||    ||.::|.|            |.|.. ||.| :.::|
  Rat    60 WVLPLDPNG-------KPEKCLRFV----HLPNASLP------------NDTQRATEPCLDGWIY 101

  Fly   141 GSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMALTGV 205
            .|:..|||.:|.|.|..|..| ....:|..||::||..:.|.|:||:|||.|..:..:.:|.:|.
  Rat   102 NSTRDTIVIEWDLVCSSNKLK-EMAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGS 165

  Fly   206 AQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALL-GLSV 269
            ..|.|.....::.|..|.....||:.....|:.||.|....|.:||..:.|.|.:|:.:| ||:.
  Rat   166 GAAFSPSLPVYMIFRFLCGCSISGISLSTVILNVEWVPTSMRAISSTSIGYCYTIGQFILSGLAY 230

  Fly   270 FLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDISVELMASF 334
            .:|.||.|||..|.|..|.....|.||||:|||:...:..:|...::|.|..|.:
  Rat   231 AIPQWRWLQLTSSAPFFIFSLLSWWVPESIRWLVLSGKYSKALKTLQRVATFNGK---------- 285

  Fly   335 KQQELDAETGQEDDVEG-GLHVKKD---DKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYYGL 395
                  .|.|::..:|. ..:::||   .|:...:.::.|..||......|.|.|......||.|
  Rat   286 ------KEEGKKLTIEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFSTGFAYYSL 344

  Fly   396 SLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQGD 460
            ::.......|.|:...:...|:||...:..|.|...|||:..|..|||.....:|..||
  Rat   345 AMGVEEFGVNIYILQIIFGGVDIPAKFITILSLSYLGRRITQSFLLLLAGGAILALIFV------ 403

  Fly   461 WIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFARF 525
              |.:..:           |...|.:.||..::.||:.::.:|:|:.|||:|..|:|:.:.:||.
  Rat   404 --PSEMQL-----------LRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNVWARV 455

  Fly   526 GAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576
            |:|:||.|.:.......:|.::|||.:|:.|..:..|.||.||.||:|:|:
  Rat   456 GSMIAPLVKITGELQPFIPNVIFGTTALLGGSAAFFLLETLNRPLPETIED 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	168/556 (30%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	110/379 (29%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	168/556 (30%)
		MFS	124..492	CDD:119392	115/402 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.030