DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and slc22a21

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001295487.1	Gene:	slc22a21 / 799908	ZFINID:	ZDB-GENE-091118-62	Length:	546	Species:	Danio rerio

Alignment Length:	577	Identity:	187/577 - (32%)
Similarity:	296/577 - (51%)	Gaps:	75/577 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DFDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANW 78
            |:::....:|.:|.||:..:.|:||.::......||.||...:|.:.|.:||...|.     |.|
Zfish     5 DYEEQTAFLGAWGPFQKTVFSLLCLSIIPNGFTGLSIVFLGDTPAHHCRIPETLNLT-----AGW 64

  Fly    79 VSIAVPGSWSKRGHFTP--STCERF-------VANGDHLESSSDPWSAWPLDQCFAENFTTETER 134
            .:.:||   ..:.|..|  |.|.|.       .::|..|.......|..|.::| |:.:..:.|
Zfish    65 RNASVP---RPQPHGDPRASRCYRLRLDLVKNYSDGGLLPGLDVNVSEIPREEC-ADGWIYDKE- 124

  Fly   135 CNQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVF 199
                :|.|   |||.:|.|.|.:: ||.....:|.|.|::.|:.:||.::||:|||.:....:..
Zfish   125 ----IYSS---TIVSEWDLVCSDD-WKSPLTSSIFFCGVLTGSVISGPVSDRFGRKIVLFVTMAI 181

  Fly   200 MALTGVAQAL--SWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREM-SSIVLNYFYAVG 261
            ..|..|.|..  ||....||||.:  .:|....|..||::|:|::....|:: |::.:..|:::|
Zfish   182 QTLFTVVQVFSPSWQIFCFLFFIV--GMGQISNYVAAFVLGMEILSSSVRDVYSTLGVCLFFSIG 244

  Fly   262 EALLGLSV-FLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNR-- 323
            ..:|.|:. ||.|||.|.|||::|....:..:|.:|||.||||::.|.::|..|||:|||:||
Zfish   245 YMILPLAAFFLRDWRSLMLALTIPGFFYIPLWWFIPESPRWLLSQGRVQEAEAIIRKAAKINRVT 309

  Fly   324 -RDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAV 387
             .|:...||.|           .||  .||:..       .:|.|:.:|..:.....:|.|||..
Zfish   310 APDVIFPLMQS-----------TED--AGGVQS-------FSVCELLKSSNIRYMTGLLCLIWMA 354

  Fly   388 NAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASG 452
            .:|.|..||||.:||.||.|||..|..:||:|...:|||.||...||..|:.:|.|..:..:
Zfish   355 VSIGYCALSLNTSSLHGNIYLNCLLSAVVEVPALLMAWLMLRLAPRRHCLASTLALGGLVLL--- 416

  Fly   453 FVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVG 517
            .:.|...|    |:.|            .:.|.::||.|::::|::||..|||:.|||:|:..:|
Zfish   417 LILLIPED----QSSV------------TLALVMLGKFGLSAAFSIIYPVTAELYPTVLRNTALG 465

  Fly   518 VMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTV 574
            ..|..:|.|.:.||:...|.||:..||.:|.|.:::::||||.||||:....||:|:
Zfish   466 ACSMSSRVGGISAPYFNYLGSYHRSLPYILIGGINVLSGLLSFLLPESRGSALPETI 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	185/565 (33%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	128/381 (34%)
slc22a21	NP_001295487.1	2A0119	14..521	CDD:273328	185/565 (33%)
slc22a21	NP_001295487.1	MFS	146..511	CDD:119392	138/405 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020