DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and oct2

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001107932.1	Gene:	oct2 / 797890	ZFINID:	ZDB-GENE-080204-92	Length:	554	Species:	Danio rerio

Alignment Length:	572	Identity:	163/572 - (28%)
Similarity:	281/572 - (49%)	Gaps:	64/572 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DFDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPEC-DKLVDAEYGAN 77
            :||::|...|:||.:|:|..:|..||:|..|...:..||...:|.:.|..... :|...:|....
Zfish     3 NFDELLQHAGDFGFYQKRISVLGSLPILLLAFVLIGVVFLGYTPDHWCKTASLQEKCGFSEEQVR 67

  Fly    78 WVSIAVPGSWSKRGHFTPSTCERF---VANGDHLESSSDPWSAWPLDQCFAENFTTETERCNQ-F 138
            .:::...|:   ||.|  |.|.:|   :.||..|..:...:           |.:|....||: :
Zfish    68 DLTVPRTGA---RGAF--SKCVKFDDALRNGSALSCNISIF-----------NNSTHLSACNEGW 116

  Fly   139 VYGSSERTIVQQWGLQCPENLWKLAFVGTIHFA-GLVVGTALSGYLADRYGRKHIFLFCIVFMAL 202
            .:..:..|||.::.|.| |:.| ||.:..:..| |..:|..::||||||:|||..|:..|..:.:
Zfish   117 TFNENRTTIVTEFSLVC-EDSW-LADLNQVSLAGGFFIGALVTGYLADRFGRKSCFIASIFGLGV 179

  Fly   203 TGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALL-G 266
            :|.....|..|...|||..|......|.:...:::.:|..|...|:..|::...||::|..|| .
Zfish   180 SGTCIIFSPYYPLLLFFRCLQGFFAKGAWTATYVLIIEFFGSNNRKFVSVMSRTFYSLGLVLLPA 244

  Fly   267 LSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDISVELM 331
            |:.::|.||.||||:::|..|.:.|.|::|||.||||::.:.::|..|::..||.|:|.:
Zfish   245 LAYYIPSWRNLQLAMTLPTFIFLIYHWVIPESPRWLLSQRKTKEALSIVKSIAKCNKRSL----- 304

  Fly   332 ASFKQQELDAETGQEDDVEGGLHVKKDDKIWL-AVKEVARSHILMGRYAILLLIWAVNAIVYYGL 395
                         .||..|..|.::|.::|.. :.|::.::..:.....||:..|...|:|:.||
Zfish   305 -------------PEDFHEMDLLIEKQEEIMRPSYKDLFKTPKMRKHTFILIYAWFTGAVVFQGL 356

  Fly   396 SLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQGD 460
            .|.......|.:|:|.:..:||:|...:.:..:.|.|||..::....:....|:|..|::
Zfish   357 VLRLGITGDNVFLDFLISAVVELPTGLIFYFLVDRIGRRPLMATVNFIGGAACLAVPFIS----- 416

  Fly   461 WIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFARF 525
                          ...:||..|:.:||:|.:......:.....|:.||.:|:.||.|.|:.:..
Zfish   417 --------------PNISWLRRTIAIVGRLAVAIGNETVNFANTELYPTPLRNLGVSVCSSASDI 467

  Fly   526 GAMLAPFVPL-LASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576
            ||::|||:.. |||.:..||||::|.:|::...|.:||||.....||:||::
Zfish   468 GAVVAPFILYRLASIWQELPLLVYGVMSVLYSGLVMLLPEMKGVDLPETVDD 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	158/558 (28%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	105/377 (28%)
oct2	NP_001107932.1	2A0119	12..516	CDD:273328	158/558 (28%)
oct2	NP_001107932.1	MFS	123..506	CDD:119392	123/421 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930