DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and slc22a7a

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001077330.1	Gene:	slc22a7a / 794188	ZFINID:	ZDB-GENE-050506-52	Length:	560	Species:	Danio rerio

Alignment Length:	575	Identity:	156/575 - (27%)
Similarity:	259/575 - (45%)	Gaps:	67/575 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDA-----EY 74
            |:|:|.|||.|.:||.....::.||.:....:.|.:.|.:|.|.:.|.:|..|....|     |.
Zfish     3 FEDVLREIGGFNKFQFLVLYILWLPRVILPLHFLLHNFISGVPPHHCALPRLDGRFSASGAEKEE 67

  Fly    75 GANWVSIAVP----GSWSKRGHFT-PSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETER 134
            .|..|::.:|    ||:|....:| |..   |..|||             |...:..........
Zfish    68 LAQIVALGIPRNSDGSYSSCKMYTMPMD---FDLNGD-------------LSVLYGNRSNVSVPC 116

  Fly   135 CNQFVYGSSE--RTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCI 197
            .|.:||..|:  .|...:|.|.|.......| :.|..|.|:.:|..:.|.|:|::|||.:.....
Zfish   117 QNGWVYDRSQFTSTTATEWDLVCDNKKLNQA-LATFFFIGVTMGAVVFGQLSDKFGRKPMIQVSF 180

  Fly   198 VFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGE 262
            |..|:.|:.:|.|..|:.|.....|.....:|:......:.||....:.|..:..:::..::||.
Zfish   181 VSSAVFGIIEAFSSSYVMFAIARTLCGFALTGMSITTVALCVEWTDVKHRTFTGTIISLGWSVGN 245

  Fly   263 ALLGLSVFL-PDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDI 326
            .||.|..:| .|||.|.|.::.|.|:.:..:|.:|||.|||||..|.|:|...:...||:|.:
Zfish   246 MLLALLAYLIRDWRHLILVVTSPCLVGIIAWWWIPESARWLLANGRVEEAQKYLINCAKMNGK-- 308

  Fly   327 SVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILL--LIWAVNA 389
                 .|: .::||.|..::      :.:.:|.....:..::.|:..|  |..:|.  :.|...|
Zfish   309 -----YSY-TKKLDIENLKK------ITIAEDSNKNHSYLDLVRTPKL--RKIVLCSGIFWFAVA 359

  Fly   390 IVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFV 454
            ..|||:|.|.|....|.||...:..::|:|.....:|.|.|.|||...:.||::..   ...|..
Zfish   360 FTYYGISFNITGFGLNIYLTQFIYGVIEVPAKVGTYLTLDRIGRRNGQAWSLIIAG---ALIGLN 421

  Fly   455 TLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVM 519
            ::...::...:||:.                ::||....::|.:.:.:|:|:.|||:|..|:|..
Zfish   422 SVIPTEFAAVRTGIA----------------VIGKGFSEAAFTIAFLYTSELYPTVLRQCGLGYT 470

  Fly   520 STFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTV 574
            |..||.|..|||.|.|....:...|.::|...::.:|.:..|||||.|.:||:.:
Zfish   471 SFIARIGGSLAPMVILFEDIWHYGPPVVFSATAVFSGCVVFLLPETTNVQLPENI 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	151/564 (27%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	102/377 (27%)
slc22a7a	NP_001077330.1	2A0119	11..523	CDD:273328	150/563 (27%)
slc22a7a	NP_001077330.1	MFS	148..514	CDD:119392	107/400 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920