DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and SLC22A2

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_003049.2	Gene:	SLC22A2 / 6582	HGNCID:	10966	Length:	555	Species:	Homo sapiens

Alignment Length:	577	Identity:	176/577 - (30%)
Similarity:	273/577 - (47%)	Gaps:	68/577 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANW-- 78
            ||:|...|||..||::.:.|:.|.....|...:..||...:|.:||..|   .:.:......|
Human     6 DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSP---GVAELSLRCGWSP 67

  Fly    79 ---VSIAVPGSWSKRGHFTPSTCERFVANG--------DHLESSSDPWSAWPLDQCFAENFTTET 132
               ::..|||. ...|..:|..|.|:..:.        |.|.|.....|..||..|
Human    68 AEELNYTVPGP-GPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPC--------- 122

  Fly   133 ERCNQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCI 197
              .:.:||.:...:||.::.|.| .|.|.|....:....|..:|:...||:|||:|||...|..:
Human   123 --RDGWVYETPGSSIVTEFNLVC-ANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTV 184

  Fly   198 VFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGE 262
            :..|..||..|:|..|...|.|.|:..:.:...:.:.:|:..|.||.|.|....|.....|.||.
Human   185 LINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGL 249

  Fly   263 ALL-GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDI 326
            .:| |::..||.||.||..:|:|....:.|:|.:|||.|||:::|:..:|..||:..||.|.:
Human   250 LVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGK-- 312

  Fly   327 SVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIV 391
              .|.||.::..|:.|||           ||.:..:|   ::.|:..:.....||:..|..::::
Human   313 --SLPASLQRLRLEEETG-----------KKLNPSFL---DLVRTPQIRKHTMILMYNWFTSSVL 361

  Fly   392 YYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTL 456
            |.||.::......|.||:|....|||.|...:..|.:.|.|||...:.|.::....|:||.|:
Human   362 YQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFI-- 424

  Fly   457 AQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMST 521
             .||                ..||.:.:..:|::|||.::.::....||:.||.||:.||.:.|:
Human   425 -PGD----------------LQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSS 472

  Fly   522 FARFGAMLAPF-VPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEA 577
            ....|.::.|| |..|.:.:..|||::||.|.||||.|.||||||..:.||:|:|||
Human   473 MCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEA 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	169/564 (30%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	113/376 (30%)
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	169/564 (30%)
SLC22A2	NP_003049.2	MFS	124..492	CDD:119392	121/405 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.930