DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and SLC22A3

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_068812.1	Gene:	SLC22A3 / 6581	HGNCID:	10967	Length:	556	Species:	Homo sapiens

Alignment Length:	586	Identity:	179/586 - (30%)
Similarity:	292/586 - (49%)	Gaps:	72/586 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPT-YRCYVPECDKLVDAEYGANW 78
            ||:.|..:|||||||||.:||:||..:..|...:..||....|. |.|..|....|.:.   ..|
Human     4 FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAER---CGW 65

  Fly    79 VSIAVPGSWSK-----RGHFTP---STCERFV-------ANGDHLESSSDPWSAWPLDQCFAENF 128
               :....|::     ||...|   ..|:|::       |:.....|.:||.:|:|       |.
Human    66 ---SPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFP-------NR 120

  Fly   129 TTETERC-NQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHI 192
            :.....| ..:.|..:..|||.::.|.| .|.|.|.....|...|.:.|....||.||||||..|
Human   121 SAPLVPCRGGWRYAQAHSTIVSEFDLVC-VNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVI 184

  Fly   193 FLFCIVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYF 257
            :|...:.:.:|||..|.:.::..|:.|..|..|...|.:...::|..|:||.::|.:..||:..|
Human   185 YLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMF 249

  Fly   258 YAVGEALL-GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKV 321
            :.:|..:| |::.|:|:|:.:|||:::|..:.:.|:|:||||.|||:.|.:.::|..|:||.||.
Human   250 FTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKC 314

  Fly   322 NRRDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWA 386
            |.:.:|         ......|..:::|...           :..::.|:..:.....||:..|.
Human   315 NGKYLS---------SNYSEITVTDEEVSNP-----------SFLDLVRTPQMRKCTLILMFAWF 359

  Fly   387 VNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVAS 451
            .:|:||.||.:....:.||.|::|.:..:||:||..|..|.:.|.|||:..:.|.::..:.|:.:
Human   360 TSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVT 424

  Fly   452 GFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGV 516
            .|  |.:|                 ..||..|:..:|:||||.:|.::|...:|:.||.:|:.||
Human   425 AF--LPEG-----------------IAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGV 470

  Fly   517 GVMSTFARFGAMLAPFVPL-LASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIAL 580
            .:.|....||.::|||:.. ||:.:..|||::||.|:.:.|.|.:|||||....||:||::...|
Human   471 SLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKL 535

  Fly   581 G 581
            |
Human   536 G 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	172/568 (30%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	112/375 (30%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	172/568 (30%)
SLC22A3	NP_068812.1	MFS	149..518	CDD:119392	124/407 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153811
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.946395	Normalized mean entropy	S3851
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.810