Protein Alignment CG4630 and SLC22A1

DIOPT Version :9

• Sequence 1: NP_001260948.1
• Gene: CG4630 / 36458
• FlyBaseID: FBgn0033809
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_005267159.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 610
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 165/548 - (30%)
• Similarity: 261/548 - (47%)
• Gaps: 68/548 - (12%)

  Fly    16 DDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANW-- 78
            ||||.::||.|.||::.:|::||.....|...:..||...:|.:.|..|   .:.:......|
Human     5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSP---GVAELSQRCGWSP 66

  Fly    79 ---VSIAVPGSWSKRGHFTPSTCERFVANG--------DHLESSSDPWSAWPLDQCFAENFTTET 132
               ::..||| ....|......|.|:..:.        |.|.|.:...|..||..|
Human    67 AEELNYTVPG-LGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPC--------- 121

  Fly   133 ERCNQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCI 197
              .:.:||.:...:||.::.|.|.:: |||....:...||.:.|:...||.|||:|||...|..:
Human   122 --QDGWVYDTPGSSIVTEFNLVCADS-WKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTV 183

  Fly   198 VFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVG- 261
            :..|::||..|.|.:|:|.|.|.||..:.:.|.:...:.:..|.||...|...:|:....:.||
Human   184 LVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGL 248

  Fly   262 EALLGLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDI 326
            .||.||:..||.||.||||:|:|..:.:.|:|.||||.||||::.|..:|..|:...|:.|.:..
Human   249 VALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLP 313

  Fly   327 SVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIV 391
            ..:|    |...|      |:||        .:|:..:..::.|:..|..|..||:.:|..::::
Human   314 PADL----KMLSL------EEDV--------TEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL 360

  Fly   392 YYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTL 456
            |.||.|:..:.|||.||:|....||||||..:|.:.:.|.||...::.|.||....|:...|::
Human   361 YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFIS- 424

  Fly   457 AQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMST 521
                              ...:||.:.:..||::|||.:..:|....||:.||.:|:.||.|.|:
Human   425 ------------------PDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSS 471

  Fly   522 FARFGAMLAPFVPL-LASYYDPLPLLLF 548
            ....|.::.||:.. |...:..|||:||
Human   472 LCDIGGIITPFIVFRLREVWQALPLILF 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	161/541 (30%)
		MFS	158..533	CDD:119392	120/375 (32%)
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	159/539 (29%)
		MFS	118..484	CDD:119392	129/414 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153734
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.960