DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and Slc22a21

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_062697.1	Gene:	Slc22a21 / 56517	MGIID:	1929481	Length:	564	Species:	Mus musculus

Alignment Length:	579	Identity:	180/579 - (31%)
Similarity:	311/579 - (53%)	Gaps:	67/579 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLDFDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGA 76
            :||:|::...:||:|.|||..:.|:...::......||.||....|.:||.:|:...|..|
Mouse     1 MLDYDEVTAFLGEWGTFQRLIFFLLSASIIPNGFTGLSAVFLTAIPEHRCRIPDTVNLSSA---- 61

  Fly    77 NWVSIAVPGSWSKRGHFTPSTCERF----VANGDHLESSSDPWSAWPLDQCFAENFTTETERC-- 135
             |.:.::|.. :|.|...|..|.|:    :||...|  ..:|.....|:|       .|.|.|
Mouse    62 -WRNHSIPME-TKDGPEVPQKCRRYRLATIANFSEL--GLEPGRDVDLEQ-------LEQENCLD 115

  Fly   136 ----NQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFC 196
                ::.::.|   |||.:|.|.|.:: ||.....:..:.|:::|:.:||.|:||:|||:| ||.
Mouse   116 GWEYDKDIFLS---TIVTEWDLVCKDD-WKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNI-LFL 175

  Fly   197 IVFMALTGVA--QALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREM-SSIVLNYFY 258
            .:.|. ||.:  |..|.::..|.....|..:|....|..||::|.||:....|.: :::.:..|:
Mouse   176 TMAMH-TGFSFIQVFSVNFEMFTLLYTLVGMGHISNYVAAFVLGTEMLSKSVRIIFATLGVCIFF 239

  Fly   259 AVGEALLGL-SVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVN 322
            |.|..:|.| :.|:.:||:|.||:::|.::|.|.:|.:|||.|||:::.|.::|.||||:|||:|
Mouse   240 AFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKIN 304

  Fly   323 RRDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAV 387
            .......:....:..:|..::.::....   |          :.::.|:..:.....:.:::|..
Mouse   305 GIVAPSTIFDPSETNKLQDDSSKKPQSH---H----------IYDLVRTPNIRILTIMSIILWLT 356

  Fly   388 NAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASG 452
            .::.|:||||:..:|:||.|:|..|:..||:|.|.||||.|:...||.:::|||.|        |
Mouse   357 ISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFL--------G 413

  Fly   453 FVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVG 517
            ...|.....:|           |..::|..||.:|||.||||:::::|.:|||:.|||:|:.|||
Mouse   414 GSVLLLVQLVP-----------SDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVG 467

  Fly   518 VMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576
            |.||.:|.|::|:|:...|.:|...||.:|.|:|:::..:::|..||:....||:|::|
Mouse   468 VSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFPESSGVSLPETIDE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	175/563 (31%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	123/378 (33%)
Slc22a21	NP_062697.1	2A0119	12..523	CDD:273328	175/563 (31%)
		MFS	123..513	CDD:119392	138/427 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.890