DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and SLC22A11

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_060954.1	Gene:	SLC22A11 / 55867	HGNCID:	18120	Length:	550	Species:	Homo sapiens

Alignment Length:	583	Identity:	159/583 - (27%)
Similarity:	267/583 - (45%)	Gaps:	80/583 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANW- 78
            |..:|.:.|..|.||....|...||.|...:..|...|:|..|.:||:....|.  .:....|.
Human     3 FSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDN--GSAVSTNMT 65

  Fly    79 ----VSIAVPGSWSKRGHFTPSTCERFVANGDHL---ESSSDPWSAWPLDQCFAENFTTETERC- 135
                ::|::|.. ..:|   |..|.||......|   .:::..||            ..:||.|
Human    66 PKALLTISIPPG-PNQG---PHQCRRFRQPQWQLLDPNATATSWS------------EADTEPCV 114

  Fly   136 NQFVYGSS--ERTIVQQWGLQC-PENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCI 197
            :.:||..|  ..|||.:|.|.| .:.|..|:  .:|..:|::||:.:.|.|:.|:|||.:..:|.
Human   115 DGWVYDRSVFTSTIVAKWDLVCSSQGLKPLS--QSIFMSGILVGSFIWGLLSYRFGRKPMLSWCC 177

  Fly   198 VFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGE 262
            :.:|:.|.:...:..::.:.....:.|.|.:|::..:..:.||.....:|.::..|:...::.|:
Human   178 LQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQ 242

  Fly   263 ALL-GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVN---- 322
            |.| ||:..|.|||.||||.|||........|.:|||.|||:.:.:.:||...:|:.|::|
Human   243 AALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKE 307

  Fly   323 RRDISVE-LMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWA 386
            .:::::| ||:|.|::...|:..:                  :|.::....:|..|...:|::..
Human   308 AKNLTIEVLMSSVKEEVASAKEPR------------------SVLDLFCVPVLRWRSCAMLVVNF 354

  Fly   387 VNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVAS 451
            ...|.||||..:..||..:.:|..||...|:..|.:...|.|...|||...:||..:..:..:|:
Human   355 SLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILAN 419

  Fly   452 GFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGK--LGITSSFAVIYTFTAEMMPTVIRSG 514
            ..|..      ..||             |.|...::||  .||:.:...||  .||:.||.:|..
Human   420 MLVPQ------DLQT-------------LRVVFAVLGKGCFGISLTCLTIY--KAELFPTPVRMT 463

  Fly   515 GVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSL-LLPETFNRKLPDTVEE 576
            ..|::.|..|.|||:.|.:.:.......||.||:|.:|:.:.|:.| .||||....||||:::
Human   464 ADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQD 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	155/570 (27%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	103/382 (27%)
SLC22A11	NP_060954.1	Sugar_tr	11..523	CDD:331684	155/570 (27%)
SLC22A11	NP_060954.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153217
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.960