DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and slc22a16

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001020659.1	Gene:	slc22a16 / 557279	ZFINID:	ZDB-GENE-041001-166	Length:	565	Species:	Danio rerio

Alignment Length:	589	Identity:	174/589 - (29%)
Similarity:	269/589 - (45%)	Gaps:	75/589 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEY-GANW 78
            ||    |:|.|.|||...|.......:....:.|:.||...:|.:.|..|.  .:.|..| ..::
Zfish     9 FD----ELGHFKRFQACLYFAAIFQAISCGIHYLASVFLVETPKFLCNPPL--NITDVLYKNLSF 67

  Fly    79 VSIAVPGSWSKRGHFTPSTCERFV--ANGDHLESSSDPWSAWPLDQCF------AENFTTE---- 131
            .|:|  ..|:   |:........|  :.||.          |.|..|.      |.||..|
Zfish    68 TSLA--DIWT---HYKTGDGPVVVRTSQGDQ----------WELSPCLKALRLDAINFQYEFFGN 117

  Fly   132 --TERCNQFVYGSS--ERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHI 192
              .|.|..|||..|  |::||..|.|.| |..|...........|:::|..:.|..|||.||:.:
Zfish   118 KSVESCGAFVYDHSEVEQSIVTDWDLVC-EREWLAKLTQPTFMLGVLIGALMFGDAADRIGRRPV 181

  Fly   193 FLFCIVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYF 257
            .:...:...:.||..|.:.:|..|:....|.|..:||...:.|:...|..|.:.|..:|:.::..
Zfish   182 LMATSLCQFIFGVTVAFTGNYYLFVVMRFLLATVSSGYLVVVFVYVTEFTGIKVRTWTSMHVHAA 246

  Fly   258 YAVG---EALLGLSVFLPDW--RQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRR 317
            :|||   .||:|..|.:  |  .|:.|.||..|.:  .|.|..||:..:|:|:.|.::|..::..
Zfish   247 FAVGIMVVALVGYLVRV--WWIYQIILTLSTSPFL--LYCWKFPETPFYLMAKGRYKEAQELLDT 307

  Fly   318 AAKVNRRDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILL 382
            .|.:|  .:...|..|..|...| .|..:|:.: .:.|:|.    |::.::..|..:.||.|...
Zfish   308 MAYIN--GLPPTLKVSDLQDGCD-RTPLKDNKQ-AMEVEKR----LSMLDMFGSLKMAGRSATCW 364

  Fly   383 LIWAVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSIT 447
            .||.:.::.||..||.:.:|.||:|:|..|...||:|.|.:....:.||||:...:.:|||..:.
Zfish   365 AIWFIGSLGYYVFSLGSVNLGGNQYINLFLAGAVEVPSYLIGCFAMDRFGRKKTCAPALLLGGVA 429

  Fly   448 CVASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIR 512
            |:.  .:.:.|        .||.         |.:.|.:.||..|..:|.:||.:|.|:.||:||
Zfish   430 CML--IIVVPQ--------DVEV---------LAIVLSMTGKFAIAIAFGLIYLYTCELYPTIIR 475

  Fly   513 SGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEA 577
            |..||..|...|.|:::|||...||..:..||.|:.|.|:.:.|:|::.||||....|..|:|||
Zfish   476 SLAVGSGSMMCRVGSVVAPFCVYLADIWIYLPQLIVGILAFIIGILTMFLPETLGEPLTSTLEEA 540

  Fly   578 IALG 581
            .|||
Zfish   541 EALG 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	164/571 (29%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	108/379 (28%)
slc22a16	NP_001020659.1	2A0119	13..536	CDD:273328	164/571 (29%)
slc22a16	NP_001020659.1	MFS	158..526	CDD:119392	117/398 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.930