DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and slc22a15.1

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_031751719.1	Gene:	slc22a15.1 / 448510	XenbaseID:	XB-GENE-959503	Length:	560	Species:	Xenopus tropicalis

Alignment Length:	590	Identity:	165/590 - (27%)
Similarity:	271/590 - (45%)	Gaps:	114/590 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PAAGAASAVLDFDDILVEIGEFGRFQ-RRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECD 67
            |.:|.....::.:..|..:||.|.:| ..::||..|..|::|..::.......:|.|
Frog    18 PCSGRRVPQMEVEGALKLVGEMGIYQIYLSFLLAVLLQLYSATEAIIITILGATPPY-------- 74

  Fly    68 KLVDAEYGANWV--SIAVPGSWSKR-GHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFT 129
                     :|:  |:...||..|: |...|       |.|:|..            ..|..|||
Frog    75 ---------HWMNDSLTANGSRGKQYGSQLP-------AEGEHGH------------VVFDGNFT 111

  Fly   130 TETERCNQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFL 194
                            :||.:|.| .....::::...:::|.|:::|....|.|:||:|||.:::
Frog   112 ----------------SIVSEWFL-VGGAAYEVSVSSSVYFGGVLIGVISFGQLSDRFGRKPVYV 159

  Fly   195 FCIVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYA 259
            ..:....:..|..||:..:..||....|..|...|:..:||::..|.:|......:..:.:..:|
Frog   160 TGLALEVVFAVMNALTPIFPLFLLTRFLVGVMNGGMSLVAFVLLNECIGASYWAAAGSLGSLCFA 224

  Fly   260 VGEALLGL-SVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNR 323
            ||.|...| ..|:..||.|.|.::|.....:|....:|||.|||.|:.|..:|...:....:.||
Frog   225 VGIAQFALIGYFIRSWRLLALLVNVQGAAVLALSLCIPESPRWLHAQGRLREAQESLLSLGRRNR 289

  Fly   324 RDISVELMASF----KQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLI 384
            |.::     ||    :|                    ||......:..:..:.||..|..|::.:
Frog   290 RKVT-----SFTLCPRQ--------------------KDSAHSANILTIYSNAILRQRTLIMMWV 329

  Fly   385 WAVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFL--RRFGRRVALSGSLLLCSIT 447
            |.|.::|||||:|::..|.|:.|||.||..|.|:|.|.|....:  :|.|||.:|:|.|
Frog   330 WFVCSLVYYGLTLSSGDLGGDIYLNLALSGLAELPAYPLCMYLINHKRVGRRGSLAGFL------ 388

  Fly   448 CVASGFVTLAQGDWIPCQTG------VESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEM 506
            ||..|...|..  .:|.:||      :.|:           ||.|:|||.|:::|.::|.:::|:
Frog   389 CVGGGACLLIM--LVPGKTGSGPLSVLNSQ-----------TLSLLGKLNISAAFNIVYIYSSEL 440

  Fly   507 MPTVIRSGGVGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLP 571
            .||.:|:.|:||.|.|:|.|.::|||:|.|...:..||.::||...:.|||||||||||.:..||
Frog   441 YPTCVRNLGMGVCSMFSRIGGIIAPFIPALRFAHWALPFIVFGAAGVSAGLLSLLLPETLSAPLP 505

  Fly   572 DTVEE 576
            :|:.:
Frog   506 ETLAD 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	161/566 (28%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	112/387 (29%)
slc22a15.1	XP_031751719.1	MFS	90..497	CDD:421695	139/486 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930