DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and CG6356

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster

Alignment Length:	601	Identity:	163/601 - (27%)
Similarity:	257/601 - (42%)	Gaps:	104/601 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DILVE----IGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYR-CYVPECDKLVDAEYGA 76
            |:|.:    :|..|.|....:.|...|.:....:..||......|..: |.:||   |.|    .
  Fly    22 DLLTKQLEVVGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPE---LQD----T 79

  Fly    77 NWV-----SIAVPG---------SWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAEN 127
            ||.     .|...|         .|: .||....:.|..:....||...|.|...    .|..:
  Fly    80 NWTHAQKREIVAKGLDSGGCTVWDWN-YGHLAKMSYEAALNYTGHLTQISPPAEV----SCRVK- 138

  Fly   128 FTTETERCNQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHI 192
                    .|..:...|.|.|..|.|.|..::.:.:...:|.. |...|:...|.|||::|||..
  Fly   139 --------GQHEFAHPETTFVADWDLTCDRSIQRTSAQVSISL-GKFCGSFSFGILADKFGRKSS 194

  Fly   193 FLFCIVFMALTGVAQALSWDYISFLF--FALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLN 255
            |.....|..:.......|..|..||.  |||  ...:||::..||.:.||.:..:.|...||..:
  Fly   195 FTLGAAFFIVGSFFCTFSPWYSLFLAGRFAL--GAASSGLFYPAFTMIVENICLKHRSWMSIAFS 257

  Fly   256 YFYAVGEALLGL-SVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAA 319
            ..|.||..:|.: ...:..||.|||||::|.|:.:...:|:.||.|||:...|.::...|:.|..
  Fly   258 ASYPVGMIILAIVGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQP 322

  Fly   320 ---KVNRRDISVELMASFKQQELDAETG-------QEDDVEGGLHVKKDDKIWLAVKEVARSHIL 374
               ::.....:...:||.| :.|:.|.|       :...::..:.:..:.|:         ..::
  Fly   323 SHYQIQPAVAAPSQVASDK-KSLEPEEGFSFGQKLKNGPLKSIIELYANSKV---------RRMI 377

  Fly   375 MGRYAILLLIWAVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVAL-- 437
            ...|    .::.|.::.||..:|||.:||.::||......||:||.|.:..:.||..|||:..
  Fly   378 FASY----FMFCVTSLSYYVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMF 438

  Fly   438 ----SG-SLLLCSITCVASGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFA 497
                :| ||||  :..|.:|..|     ||                   |...::|:.||:::::
  Fly   439 LFLWTGVSLLL--VLAVPAGSTT-----WI-------------------VAFAMLGRFGISATYS 477

  Fly   498 VIYTFTAEMMPTVIRSGGVGVMSTFARFGAMLAPF-VPLLASYYDPLPLLLFGTLSLVAGLLSLL 561
            |:..:|||:.||.||:..:|..||||..|::.||: |.:|.:....:|..:.|...||||||:|.
  Fly   478 VVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGCCVLVAGLLTLT 542

  Fly   562 LPETFNRKLPDTVEEA 577
            ||||...||.|.||.:
  Fly   543 LPETGTGKLSDKVESS 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	158/585 (27%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	108/395 (27%)
CG6356	NP_651240.1	MFS	167..544	CDD:119392	119/419 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458473
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	8.000