DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4630 and CG7084

DIOPT Version :9

Sequence 1:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	154/594 - (25%)
Similarity:	256/594 - (43%)	Gaps:	79/594 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LDFDD---------ILVEIGEFGRFQR-RNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECD 67
            :|.||         ::.:.|..||:|. .|::.:.......|...::.:.....|.:.|.||..:
  Fly    23 MDVDDSEFNDPFQALMEKAGNHGRYQTLYNFVFVGGLAFSGAMIYMNIILALNIPDHWCTVPGRE 87

  Fly    68 KLVDAEYG-ANWVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTE 131
               :..:. ..|..|.:|.....||..|.|.||.|..|...:..    ||||      ..|.|..
  Fly    88 ---NTNFSLEEWRDITLPKQADNRGRKTFSNCEMFQMNFSEITD----WSAW------NSNLTKT 139

  Fly   132 TERC-NQFVYGSS--ERTIVQQWGLQCPENLWKLAFVGTIHFAGL---VVGTALSGYLADRYGRK 190
            ||.| |.:.|..:  |.||.......|.::|    ||..:...|.   |.|:.:.|.:.|.|||:
  Fly   140 TEACQNGWSYDKTWYESTIPTDHNWVCAKDL----FVTNVFVVGRVTEVAGSFILGQMGDSYGRR 200

  Fly   191 HIFLFCIVFMALTGVAQAL-SWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVL 254
            .::...:||.:|..:...: :..|..||..:.:..:..:.::....|||:|:.....|...:...
  Fly   201 FVYYISVVFCSLGRLGSIMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQ 265

  Fly   255 NYFYAVGEALLGLSV-FLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRA 318
            :..:::|..|:.|.. :|..|.......|:|..:.:.:...|.||.|||:::.|..:|.|.:::.
  Fly   266 SCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKI 330

  Fly   319 AKVN--RRDIS-VELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAI 380
            ||:|  |.|:: .||...:.:.:.|...|......|          |    .:||:..:||
  Fly   331 AKINGHRFDMTEKELAEIYSRDKQDVTYGIASLFAG----------W----RLARNTTIMG---- 377

  Fly   381 LLLIWAVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCS 445
              ..|.|.|:.|:.|.|.::.::||.:|||....:||||.|.:.......:|||...|.|.|:..
  Fly   378 --FSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISF 440

  Fly   446 ITCVASGFVTLAQGDWIPCQT-GVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPT 509
            :||             :|... ..:.|:.    |.::.....:..|...:.|.|... ..|:.||
  Fly   441 VTC-------------LPIIVYSTDERYE----NLMIYLATFIKFLNALTFFTVNLQ-CLEIYPT 487

  Fly   510 VIRSGGVGVMSTFARFGAMLAPFVPLLASYYD-PLPLLLFGTLSLVAGLLSLLLPETFNRKLPDT 573
            .:|..||.:.:..|....:|||::..|.:..| ..|..:.|.|.|:.|:.:|.||||.::|||||
  Fly   488 CMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDT 552

  Fly   574 VEEAIALGK 582
            :|||...||
  Fly   553 MEEAGHFGK 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	144/564 (26%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	93/383 (24%)
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	139/542 (26%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	97/395 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	6.060